Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText.
Kick-your-searchterm to multiple Engines kick-your-query now !>
A dictionary by aggregated review articles of nephrology, medicine and the life sciences
Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

suck abstract from ncbi


10.1038/s42255-021-00425-4

http://scihub22266oqcxt.onion/10.1038/s42255-021-00425-4
suck pdf from google scholar
34158670!ä!34158670

suck abstract from ncbi


Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
pmid34158670      Nat+Metab 2021 ; 3 (7): 909-922
Nephropedia Template TP

gab.com Text

Twit Text FOAVip

Twit Text #

English Wikipedia


  • A multi-omics investigation of the composition and function of extracellular vesicles along the temporal trajectory of COVID-19 #MMPMID34158670
  • Lam SM; Zhang C; Wang Z; Ni Z; Zhang S; Yang S; Huang X; Mo L; Li J; Lee B; Mei M; Huang L; Shi M; Xu Z; Meng FP; Cao WJ; Zhou MJ; Shi L; Chua GH; Li B; Cao J; Wang J; Bao S; Wang Y; Song JW; Zhang F; Wang FS; Shui G
  • Nat Metab 2021[Jul]; 3 (7): 909-922 PMID34158670show ga
  • Exosomes represent a subtype of extracellular vesicle that is released through retrograde transport and fusion of multivesicular bodies with the plasma membrane(1). Although no perfect methodologies currently exist for the high-throughput, unbiased isolation of pure plasma exosomes(2,3), investigation of exosome-enriched plasma fractions of extracellular vesicles can confer a glimpse into the endocytic pathway on a systems level. Here we conduct high-coverage lipidomics with an emphasis on sterols and oxysterols, and proteomic analyses of exosome-enriched extracellular vesicles (EVs hereafter) from patients at different temporal stages of COVID-19, including the presymptomatic, hyperinflammatory, resolution and convalescent phases. Our study highlights dysregulated raft lipid metabolism that underlies changes in EV lipid membrane anisotropy that alter the exosomal localization of presenilin-1 (PS-1) in the hyperinflammatory phase. We also show in vitro that EVs from different temporal phases trigger distinct metabolic and transcriptional responses in recipient cells, including in alveolar epithelial cells, which denote the primary site of infection, and liver hepatocytes, which represent a distal secondary site. In comparison to the hyperinflammatory phase, EVs from the resolution phase induce opposing effects on eukaryotic translation and Notch signalling. Our results provide insights into cellular lipid metabolism and inter-tissue crosstalk at different stages of COVID-19 and are a resource to increase our understanding of metabolic dysregulation in COVID-19.
  • |*Lipidomics/methods[MESH]
  • |*Metabolomics/methods[MESH]
  • |*SARS-CoV-2/genetics/immunology[MESH]
  • |Biological Transport[MESH]
  • |COVID-19/epidemiology/*metabolism/*virology[MESH]
  • |Cell Fractionation[MESH]
  • |Cell Membrane/metabolism[MESH]
  • |Chemical Fractionation[MESH]
  • |Cluster Analysis[MESH]
  • |Computational Biology/methods[MESH]
  • |Exosomes/metabolism[MESH]
  • |Extracellular Vesicles/*metabolism[MESH]
  • |Host-Pathogen Interactions[MESH]
  • |Humans[MESH]
  • |Metabolome[MESH]


  • DeepDyve
  • Pubget Overpricing
  • suck abstract from ncbi

    Linkout box