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10.1212/WNL.0000000000012244 http://scihub22266oqcxt.onion/10.1212/WNL.0000000000012244 34158381!8362358!34158381     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neurology 2021 ; 97 (4): e341-e344 Nephropedia Template TP {{tp|p=34158381|t=2021. Association of Serum Magnesium Levels With Risk of Intracranial Aneurysm: A Mendelian Randomization Study |pdf=|usr=}}{{34158381}} gab.com Text Association of Serum Magnesium Levels With Risk of Intracranial Aneurysm: A Mendelian Randomization Study JO: Neurology http://www.kidney.de/pget.php?&tw=1&pmid=34158381 #FOAvip OBJECTIVE: Magnesium has been implicated in regulating blood pressure and vascular endothelial cell function, but its role in the pathophysiology of intracranial aneurysm is not known. Here we performed a Mendelian randomization analysis to investigate the association between serum magnesium concentration and risk of intracranial aneurysm. METHODS: Five single-nucleotide polymorphisms strongly associated with serum magnesium concentrations in a genome-wide association study in 23,829 individuals of European ancestry were used as genetic instruments. Genetic association estimates for intracranial aneurysm were obtained from a genome-wide association study in 79,429 individuals (7,495 cases and 71,934 controls). The inverse variance weighted method was used in the primary analyses to obtain the causal estimates. RESULTS: Higher genetically predicted serum magnesium concentrations were associated with lower risk of intracranial aneurysm. The odds ratios per 0.1 mmol/L increment in genetically predicted serum magnesium concentrations were 0.66 (95% confidence interval [CI] 0.49-0.91) for intracranial aneurysm (unruptured and ruptured combined), 0.57 (95% CI 0.30-1.06) for unruptured intracranial aneurysm, and 0.67 (95% CI 0.48-0.92) for aneurysmal subarachnoid hemorrhage. CONCLUSION: This study provides evidence to support that increased serum magnesium concentrations reduce the risk of intracranial aneurysm and associated hemorrhage. Twit Text FOAVip Association of Serum Magnesium Levels With Risk of Intracranial Aneurysm: A Mendelian Randomization Study ????Neurology http://www.kidney.de/pget.php?&tw=1&pmid=34158381 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34158381 #FOAvip English Wikipedia <ref>{{Cite pmid|34158381}}</ref> Association of Serum Magnesium Levels With Risk of Intracranial Aneurysm: A Mendelian Randomization Study #MMPMID34158381 Larsson SC; Gill D Neurology 2021[Jul]; 97 (4): e341-e344 PMID34158381show ga OBJECTIVE: Magnesium has been implicated in regulating blood pressure and vascular endothelial cell function, but its role in the pathophysiology of intracranial aneurysm is not known. Here we performed a Mendelian randomization analysis to investigate the association between serum magnesium concentration and risk of intracranial aneurysm. METHODS: Five single-nucleotide polymorphisms strongly associated with serum magnesium concentrations in a genome-wide association study in 23,829 individuals of European ancestry were used as genetic instruments. Genetic association estimates for intracranial aneurysm were obtained from a genome-wide association study in 79,429 individuals (7,495 cases and 71,934 controls). The inverse variance weighted method was used in the primary analyses to obtain the causal estimates. RESULTS: Higher genetically predicted serum magnesium concentrations were associated with lower risk of intracranial aneurysm. The odds ratios per 0.1 mmol/L increment in genetically predicted serum magnesium concentrations were 0.66 (95% confidence interval [CI] 0.49-0.91) for intracranial aneurysm (unruptured and ruptured combined), 0.57 (95% CI 0.30-1.06) for unruptured intracranial aneurysm, and 0.67 (95% CI 0.48-0.92) for aneurysmal subarachnoid hemorrhage. CONCLUSION: This study provides evidence to support that increased serum magnesium concentrations reduce the risk of intracranial aneurysm and associated hemorrhage. |Blood Pressure/*physiology[MESH] |Case-Control Studies[MESH] |Cation Transport Proteins/genetics[MESH] |Genetic Association Studies[MESH] |Genetic Predisposition to Disease[MESH] |Humans[MESH] |Intracranial Aneurysm/*blood/genetics[MESH] |MDS1 and EVI1 Complex Locus Protein/genetics[MESH] |Magnesium/*blood[MESH] |Mendelian Randomization Analysis[MESH] |Microfilament Proteins/genetics[MESH] |Mucin-1/genetics[MESH] |Plasma Membrane Calcium-Transporting ATPases/genetics[MESH] |Polymorphism, Single Nucleotide[MESH]Association of Serum Magnesium Levels With Risk of Intracranial Aneury(epmc).pdf DeepDyve Pubget Overpricing