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10.11622/smedj.2021084

http://scihub22266oqcxt.onion/10.11622/smedj.2021084
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34157808!9875876!34157808
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suck abstract from ncbi


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pmid34157808      Singapore+Med+J 2022 ; 63 (12): 715-722
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  • Predictive performance of emergency department-specific variables on COVID-19 pneumonia #MMPMID34157808
  • Tan HY; Yeo M; Tay XY; Fung M; Kumar R; Ooi ST; Amirah L; Ubeynarayana CU; Mao D
  • Singapore Med J 2022[Dec]; 63 (12): 715-722 PMID34157808show ga
  • INTRODUCTION: The majority of patients with COVID-19 infection do not progress to pneumonia. We report emergency department (ED)-specific variables and evaluate their predictive performance on diagnosis of pneumonia, intensive care unit (ICU) admission and death. METHODS: This was a retrospective, single-centre cohort study of confirmed COVID-19 patients admitted to a Singapore tertiary hospital. Primary outcome was diagnosis of COVID-19 pneumonia. Secondary outcomes were ICU admission and/or death. Multivariate logistic regression was used to analyse the predictive performance of ED-specific variables. Accuracy of continuous variables was measured by area under receiver operating characteristic (ROC) curve. RESULTS: 294 patients were included. Patients with pneumonia were older (52.0 years, P < 0.001) and had higher C-reactive protein (CRP; 33.8 mg/L, P < 0.001). Patients with indeterminate chest radiograph (CRX) findings were at risk of pneumonia vs. patients with normal CRX (37.5% vs. 4.3%, P < 0.001). Patients admitted to ICU were older (60.0 years, P < 0.001) and had higher CRP (40.0 mg/L, P < 0.001). Diagnosis of COVID-19 pneumonia was associated with ICU admission and death (30.0% vs 0.39%, P < 0.001). Multivariate logistic regression analysis showed that age (aOR 1.07, P = 0.049), CRP (aOR 1.05, P = 0.006) and CRX findings (aOR 50.00, P < 0.001) had increased odds of pneumonia. ROC curve analysis showed that CRP of 23.3 mg/L was the optimal cut-off for predicting pneumonia. CONCLUSION: Older age, higher CRP and CRX findings are associated with COVID-19 pneumonia, ICU admission and death. Prospective studies should be undertaken to validate these findings.
  • |*COVID-19[MESH]
  • |Cohort Studies[MESH]
  • |Emergency Service, Hospital[MESH]
  • |Humans[MESH]
  • |Intensive Care Units[MESH]
  • |Prospective Studies[MESH]
  • |ROC Curve[MESH]
  • |Retrospective Studies[MESH]


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