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10.1016/j.virol.2021.05.012

http://scihub22266oqcxt.onion/10.1016/j.virol.2021.05.012
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suck abstract from ncbi


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pmid34157565      Virology 2021 ; 561 (ä): 65-68
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  • Age- and airway disease related gene expression patterns of key SARS-CoV-2 entry factors in human nasal epithelia #MMPMID34157565
  • Plaas M; Seppa K; Gaur N; Kasenomm P; Plaas M
  • Virology 2021[Sep]; 561 (ä): 65-68 PMID34157565show ga
  • The global COVID-19 pandemic caused by SARS-CoV-2 predominantly affects the elderly. Differential expression of SARS-CoV-2 entry genes may underlie the variable susceptibility in different patient groups. Here, we examined the gene expression of key SARS-CoV-2 entry factors in mucosal biopsies to delineate the roles of age and existing chronic airway disease. A significant inverse correlation between ACE2 and age and a downregulation of NRP1 in patients with airway disease were noted. These results indicate that the interplay between various factors may influence susceptibility and the disease course.
  • |*Gene Expression Regulation[MESH]
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Age Factors[MESH]
  • |Aged[MESH]
  • |Biomarkers[MESH]
  • |COVID-19/*genetics/*virology[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |Comorbidity[MESH]
  • |Female[MESH]
  • |Host-Pathogen Interactions/*genetics[MESH]
  • |Humans[MESH]
  • |Infant[MESH]
  • |Infant, Newborn[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Nasal Mucosa/*metabolism/*virology[MESH]
  • |SARS-CoV-2/*physiology[MESH]
  • |Virus Internalization[MESH]


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