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10.11909/j.issn.1671-5411.2021.05.004 http://scihub22266oqcxt.onion/10.11909/j.issn.1671-5411.2021.05.004 34157060!8185447!34157060     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34157060&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       J+Geriatr+Cardiol 2021 ; 18 (5): 338-345 Nephropedia Template TP {{tp|p=34157060|t=2021. Prevalence and prognostic value of cardiac troponin in elderly patients hospitalized for COVID-19 |pdf=|usr=}}{{34157060}} gab.com Text Prevalence and prognostic value of cardiac troponin in elderly patients hospitalized for COVID-19 JO: J Geriatr Cardiol http://www.kidney.de/pget.php?&tw=1&pmid=34157060 #FOAvip BACKGROUND: Increases in cardiac troponin (cTn) in coronavirus disease 2019 (COVID-19) have been associated with worse prognosis. Nonetheless, data about the significance of cTn in elderly subjects with COVID-19 are lacking. METHODS: From a registry of consecutive patients with COVID-19 admitted to a hub hospital in Italy from 25/02/2020 to 03/07/2020, we selected those >/= 60 year-old and with cTnI measured within three days from the molecular diagnosis of SARS-CoV-2 infection. When available, a second cTnI value within 48 h was also extracted. The relationship between increased cTnI and all-cause in-hospital mortality was evaluated by a Cox regression model and restricted cubic spline functions with three knots. RESULTS: Of 343 included patients (median age: 75.0 (68.0-83.0) years, 34.7% men), 88 (25.7%) had cTnI above the upper-reference limit (0.046 microg/L). Patients with increased cTnI had more comorbidities, greater impaired respiratory exchange and higher inflammatory markers on admission than those with normal cTnI. Furthermore, they died more (73.9%vs. 37.3%, P < 0.001) over 15 (6-25) days of hospitalization. The association of elevated cTnI with mortality was confirmed by the adjusted Cox regression model (HR = 1.61, 95%CI: 1.06-2.52, P = 0.039) and was linear until 0.3 microg/L, with a subsequent plateau. Of 191 (55.7%) patients with a second cTnI measurement, 49 (25.7%) had an increasing trend, which was not associated with mortality (univariate HR = 1.39, 95%CI: 0.87-2.22, P = 0.265). CONCLUSIONS: In elderly COVID-19 patients, an initial increase in cTn is common and predicts a higher risk of death. Serial cTn testing may not confer additional prognostic information. Twit Text FOAVip Prevalence and prognostic value of cardiac troponin in elderly patients hospitalized for COVID-19 ????J Geriatr Cardiol http://www.kidney.de/pget.php?&tw=1&pmid=34157060 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34157060 #FOAvip English Wikipedia <ref>{{Cite pmid|34157060}}</ref> Prevalence and prognostic value of cardiac troponin in elderly patients hospitalized for COVID-19 #MMPMID34157060 De Marzo V; Di Biagio A; Della Bona R; Vena A; Arboscello E; Emirjona H; Mora S; Giacomini M; Da Rin G; Pelosi P; Bassetti M; Ameri P; Porto I; Gecovid Study Group J Geriatr Cardiol 2021[May]; 18 (5): 338-345 PMID34157060show ga BACKGROUND: Increases in cardiac troponin (cTn) in coronavirus disease 2019 (COVID-19) have been associated with worse prognosis. Nonetheless, data about the significance of cTn in elderly subjects with COVID-19 are lacking. METHODS: From a registry of consecutive patients with COVID-19 admitted to a hub hospital in Italy from 25/02/2020 to 03/07/2020, we selected those >/= 60 year-old and with cTnI measured within three days from the molecular diagnosis of SARS-CoV-2 infection. When available, a second cTnI value within 48 h was also extracted. The relationship between increased cTnI and all-cause in-hospital mortality was evaluated by a Cox regression model and restricted cubic spline functions with three knots. RESULTS: Of 343 included patients (median age: 75.0 (68.0-83.0) years, 34.7% men), 88 (25.7%) had cTnI above the upper-reference limit (0.046 microg/L). Patients with increased cTnI had more comorbidities, greater impaired respiratory exchange and higher inflammatory markers on admission than those with normal cTnI. Furthermore, they died more (73.9%vs. 37.3%, P < 0.001) over 15 (6-25) days of hospitalization. The association of elevated cTnI with mortality was confirmed by the adjusted Cox regression model (HR = 1.61, 95%CI: 1.06-2.52, P = 0.039) and was linear until 0.3 microg/L, with a subsequent plateau. Of 191 (55.7%) patients with a second cTnI measurement, 49 (25.7%) had an increasing trend, which was not associated with mortality (univariate HR = 1.39, 95%CI: 0.87-2.22, P = 0.265). CONCLUSIONS: In elderly COVID-19 patients, an initial increase in cTn is common and predicts a higher risk of death. Serial cTn testing may not confer additional prognostic information. ?Prevalence and prognostic value of cardiac troponin in elderly patient(epmc).pdf DeepDyve Pubget Overpricing