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10.1007/s00330-021-08122-2

http://scihub22266oqcxt.onion/10.1007/s00330-021-08122-2
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34156552!8217971!34156552
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suck abstract from ncbi


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pmid34156552      Eur+Radiol 2022 ; 32 (1): 508-516
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  • (18)F FDG uptake of axillary lymph nodes after COVID-19 vaccination in oncological PET/CT: frequency, intensity, and potential clinical impact #MMPMID34156552
  • Skawran S; Gennari AG; Dittli M; Treyer V; Muehlematter UJ; Maurer A; Burger IA; Mader C; Messerli O; Grunig H; Gebhard C; Huellner MW; Curioni-Fontecedro A; Berger C; Messerli M
  • Eur Radiol 2022[Jan]; 32 (1): 508-516 PMID34156552show ga
  • OBJECTIVES: To assess the frequency, intensity, and clinical impact of [(18)F]FDG-avidity of axillary lymph nodes after vaccination with COVID-19 vaccines BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna) in patients referred for oncological FDG PET/CT. METHODS: One hundred forty patients referred for FDG PET/CT during February and March 2021 after first or second vaccination with Pfizer-BioNTech or Moderna were retrospectively included. FDG-avidity of ipsilateral axillary lymph nodes was measured and compared. Assuming no knowledge of prior vaccination, metastatic risk was analyzed by two readers and the clinical impact was evaluated. RESULTS: FDG PET/CT showed FDG-avid lymph nodes ipsilateral to the vaccine injection in 75/140 (54%) patients with a mean SUV(max) of 5.1 (range 2.0 - 17.3). FDG-avid lymph nodes were more frequent in patients vaccinated with Moderna than Pfizer-BioNTech (36/50 [72%] vs. 39/90 [43%] cases, p < 0.001). Metastatic risk of unilateral FDG-avid axillary lymph nodes was rated unlikely in 52/140 (37%), potential in 15/140 (11%), and likely in 8/140 (6%) cases. Clinical management was affected in 17/140 (12%) cases. CONCLUSIONS: FDG-avid axillary lymph nodes are common after COVID-19 vaccination. The avidity of lymph nodes is more frequent in Moderna compared to that in Pfizer-BioNTech vaccines. To avoid relatively frequent clinical dilemmas, we recommend carefully taking the history for prior vaccination in patients undergoing FDG PET/CT and administering the vaccine contralateral to primary cancer. KEY POINTS: * PET/CT showed FDG-avid axillary lymph nodes ipsilateral to the vaccine injection site in 54% of 140 oncological patients after COVID-19 vaccination. * FDG-avid lymphadenopathy was observed significantly more frequently in Moderna compared to patients receiving Pfizer-BioNTech-vaccines. * Patients should be screened for prior COVID-19 vaccination before undergoing PET/CT to enable individually tailored recommendations for clinical management.
  • |*COVID-19[MESH]
  • |*COVID-19 Vaccines[MESH]
  • |2019-nCoV Vaccine mRNA-1273[MESH]
  • |BNT162 Vaccine[MESH]
  • |Fluorodeoxyglucose F18[MESH]
  • |Humans[MESH]
  • |Lymph Nodes/diagnostic imaging[MESH]
  • |Positron Emission Tomography Computed Tomography[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2[MESH]


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