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Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Anal+Chem 2021 ; 93 (26): 9174-9182 Nephropedia Template TP
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On-Site Detection of SARS-CoV-2 Antigen by Deep Learning-Based Surface-Enhanced Raman Spectroscopy and Its Biochemical Foundations #MMPMID34155883
Huang J; Wen J; Zhou M; Ni S; Le W; Chen G; Wei L; Zeng Y; Qi D; Pan M; Xu J; Wu Y; Li Z; Feng Y; Zhao Z; He Z; Li B; Zhao S; Zhang B; Xue P; He S; Fang K; Zhao Y; Du K
Anal Chem 2021[Jul]; 93 (26): 9174-9182 PMID34155883show ga
A rapid, on-site, and accurate SARS-CoV-2 detection method is crucial for the prevention and control of the COVID-19 epidemic. However, such an ideal screening technology has not yet been developed for the diagnosis of SARS-CoV-2. Here, we have developed a deep learning-based surface-enhanced Raman spectroscopy technique for the sensitive, rapid, and on-site detection of the SARS-CoV-2 antigen in the throat swabs or sputum from 30 confirmed COVID-19 patients. A Raman database based on the spike protein of SARS-CoV-2 was established from experiments and theoretical calculations. The corresponding biochemical foundation for this method is also discussed. The deep learning model could predict the SARS-CoV-2 antigen with an identification accuracy of 87.7%. These results suggested that this method has great potential for the diagnosis, monitoring, and control of SARS-CoV-2 worldwide.