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10.1038/s41467-021-24123-7 http://scihub22266oqcxt.onion/10.1038/s41467-021-24123-7 34155209!8217500!34155209     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2021 ; 12 (1): 3815 Nephropedia Template TP {{tp|p=34155209|t=2021. Sequence signatures of two public antibody clonotypes that bind SARS-CoV-2 receptor binding domain |pdf=|usr=}}{{34155209}} gab.com Text Sequence signatures of two public antibody clonotypes that bind SARS-CoV-2 receptor binding domain JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34155209 #FOAvip Since the COVID-19 pandemic onset, the antibody response to SARS-CoV-2 has been extensively characterized. Antibodies to the receptor binding domain (RBD) on the spike protein are frequently encoded by IGHV3-53/3-66 with a short complementarity-determining region (CDR) H3. Germline-encoded sequence motifs in heavy chain CDRs H1 and H2 have a major function, but whether any common motifs are present in CDR H3, which is often critical for binding specificity, is not clear. Here, we identify two public clonotypes of IGHV3-53/3-66 RBD antibodies with a 9-residue CDR H3 that pair with different light chains. Distinct sequence motifs on CDR H3 are present in the two public clonotypes that seem to be related to differential light chain pairing. Additionally, we show that Y58F is a common somatic hypermutation that results in increased binding affinity of IGHV3-53/3-66 RBD antibodies with a short CDR H3. These results advance understanding of the antibody response to SARS-CoV-2. Twit Text FOAVip Sequence signatures of two public antibody clonotypes that bind SARS-CoV-2 receptor binding domain ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34155209 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34155209 #FOAvip English Wikipedia <ref>{{Cite pmid|34155209}}</ref> Sequence signatures of two public antibody clonotypes that bind SARS-CoV-2 receptor binding domain #MMPMID34155209 Tan TJC; Yuan M; Kuzelka K; Padron GC; Beal JR; Chen X; Wang Y; Rivera-Cardona J; Zhu X; Stadtmueller BM; Brooke CB; Wilson IA; Wu NC Nat Commun 2021[Jun]; 12 (1): 3815 PMID34155209show ga Since the COVID-19 pandemic onset, the antibody response to SARS-CoV-2 has been extensively characterized. Antibodies to the receptor binding domain (RBD) on the spike protein are frequently encoded by IGHV3-53/3-66 with a short complementarity-determining region (CDR) H3. Germline-encoded sequence motifs in heavy chain CDRs H1 and H2 have a major function, but whether any common motifs are present in CDR H3, which is often critical for binding specificity, is not clear. Here, we identify two public clonotypes of IGHV3-53/3-66 RBD antibodies with a 9-residue CDR H3 that pair with different light chains. Distinct sequence motifs on CDR H3 are present in the two public clonotypes that seem to be related to differential light chain pairing. Additionally, we show that Y58F is a common somatic hypermutation that results in increased binding affinity of IGHV3-53/3-66 RBD antibodies with a short CDR H3. These results advance understanding of the antibody response to SARS-CoV-2. |Amino Acid Sequence[MESH] |Angiotensin-Converting Enzyme 2/chemistry/*immunology/metabolism[MESH] |Antibodies, Neutralizing/chemistry/*immunology/metabolism[MESH] |Antibody Formation[MESH] |COVID-19/*immunology/metabolism/virology[MESH] |Complementarity Determining Regions/chemistry/immunology/metabolism[MESH] |Crystallography, X-Ray[MESH] |High-Throughput Nucleotide Sequencing/methods[MESH] |Humans[MESH] |Models, Molecular[MESH] |Protein Binding[MESH] |Protein Domains[MESH] |SARS-CoV-2/*immunology/isolation & purification/metabolism[MESH]Sequence signatures of two public antibody clonotypes that bind SARS-C(epmc).pdf DeepDyve Pubget Overpricing