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10.1016/j.acvd.2021.04.002

http://scihub22266oqcxt.onion/10.1016/j.acvd.2021.04.002
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34154954!8139232!34154954
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suck abstract from ncbi


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pmid34154954      Arch+Cardiovasc+Dis 2021 ; 114 (5): 394-406
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  • Characteristics and impact of cardiovascular comorbidities on coronavirus disease 2019 in women: A multicentre cohort study #MMPMID34154954
  • Weizman O; Mika D; Cellier J; Geneste L; Trimaille A; Pommier T; Panagides V; Marsou W; Deney A; Attou S; Delmotte T; Ribeyrolles S; Chemaly P; Karsenty C; Giordano G; Gautier A; Chaumont C; Guilleminot P; Sagnard A; Pastier J; Duceau B; Sutter W; Fauvel C; Pezel T; Bonnet G; Cohen A; Waldmann V
  • Arch Cardiovasc Dis 2021[May]; 114 (5): 394-406 PMID34154954show ga
  • BACKGROUND: Although women account for up to half of patients hospitalized for coronavirus disease 2019 (COVID-19), no specific data have been reported in this population. AIMS: To assess the burden and impact of cardiovascular comorbidities in women with COVID-19. METHODS: All consecutive patients hospitalized for COVID-19 across 24 hospitals from 26 February to 20 April 2020 were included. The primary composite outcome was transfer to an intensive care unit or in-hospital death. RESULTS: Among 2878 patients, 1212 (42.1%) were women. Women were older (68.3+/-18.0 vs. 65.4+/-16.0 years; P<0.001), but had less prevalent cardiovascular comorbidities than men. Among women, 276 (22.8%) experienced the primary outcome, including 161 (13.3%) transfers to an intensive care unit and 115 (9.5%) deaths without transfer to intensive care unit. The rate of in-hospital death or transfer to an intensive care unit was lower in women versus men (crude hazard ratio [HR]: 0.62, 95% confidence interval [CI]: 0.53-0.72). Age (adjusted HR: 1.05 per 5-year increase, 95% CI: 1.01-1.10), body mass index (adjusted HR: 1.06 per 2-unit increase, 95% CI: 1.02-1.10), chronic kidney disease (adjusted HR: 1.57, 95% CI: 1.11-2.22) and heart failure (adjusted HR: 1.52, 95% CI: 1.04-2.22) were independently associated with the primary outcome in women. Elevated B-type natriuretic peptide/N-terminal prohormone of B-type natriuretic peptide (adjusted HR: 2.41, 95% CI: 1.70-3.44) and troponin (adjusted HR: 2.00, 95% CI: 1.39-2.88) concentrations at admission were also associated with the primary outcome, even in women free of previous coronary artery disease or heart failure. CONCLUSIONS: Although female sex was associated with a lower risk of transfer to an intensive care unit or in-hospital death, COVID-19 remained associated with considerable morbimortality in women, especially in those with cardiovascular diseases.
  • |Aged[MESH]
  • |Asthma/epidemiology[MESH]
  • |Biomarkers[MESH]
  • |COVID-19/*epidemiology[MESH]
  • |Cardiovascular Diseases/blood/*epidemiology[MESH]
  • |Comorbidity[MESH]
  • |Diabetes Mellitus/epidemiology[MESH]
  • |Female[MESH]
  • |France/epidemiology[MESH]
  • |Hospital Mortality[MESH]
  • |Humans[MESH]
  • |Intensive Care Units/statistics & numerical data[MESH]
  • |Length of Stay/statistics & numerical data[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Natriuretic Peptide, Brain/blood[MESH]
  • |Peptide Fragments/blood[MESH]
  • |Proportional Hazards Models[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Assessment[MESH]
  • |Risk Factors[MESH]
  • |Sex Distribution[MESH]
  • |Smoking/epidemiology[MESH]


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