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10.1016/j.thromres.2021.06.003 http://scihub22266oqcxt.onion/10.1016/j.thromres.2021.06.003 34153649!8184876!34153649     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34153649&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Thromb+Res 2021 ; 204 (?): 88-94 Nephropedia Template TP {{tp|p=34153649|t=2021. C-C motive chemokine ligand 2 and thromboinflammation in COVID-19-associated pneumonia: A retrospective study |pdf=|usr=}}{{34153649}} gab.com Text C-C motive chemokine ligand 2 and thromboinflammation in COVID-19-associated pneumonia: A retrospective study JO: Thromb Res http://www.kidney.de/pget.php?&tw=1&pmid=34153649 #FOAvip PURPOSE: A derangement of the coagulation process and thromboinflammatory events has emerged as pathologic characteristics of severe COVID-19, characterized by severe respiratory failure. CC motive chemokine ligand 2 (CCL2), a chemokine originally described as a chemotactic agent for monocytes, is involved in inflammation, coagulation activation and neoangiogenesis. We investigated the association of CCL2 levels with coagulation derangement and respiratory impairment in patients with COVID-19. METHODS: We retrospectively evaluated 281 patients admitted to two hospitals in Italy with COVID-19. Among them, CCL2 values were compared in different groups (identified according to D-dimer levels and the lowest PaO(2)/FiO(2) recorded during hospital stay, P/F(nadir)) by Jonckheere-Terpstra tests; linear regression analysis was used to analyse the relationship between CCL2 and P/F(nadir). We performed Mann-Whitney test and Kaplan-Meier curves to investigate the role of CCL2 according to different clinical outcomes (survival and endotracheal intubation [ETI]). RESULTS: CCL2 levels were progressively higher in patients with increasing D-dimer levels and with worse gas exchange impairment; there was a statistically significant linear correlation between log CCL2 and log P/F(nadir). CCL2 levels were significantly higher in patients with unfavourable clinical outcomes; Kaplan-Meier curves for the composite outcome death and/or need for ETI showed a significantly worse prognosis for patients with higher (> median) CCL2 levels. CONCLUSIONS: CCL2 correlates with both indices of activation of the coagulation cascade and respiratory impairment severity, which are likely closely related in COVID-19 pathology, thus suggesting that CCL2 could be involved in the thromboinflammatory events characterizing this disease. Twit Text FOAVip C-C motive chemokine ligand 2 and thromboinflammation in COVID-19-associated pneumonia: A retrospective study ????Thromb Res http://www.kidney.de/pget.php?&tw=1&pmid=34153649 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34153649 #FOAvip English Wikipedia <ref>{{Cite pmid|34153649}}</ref> C-C motive chemokine ligand 2 and thromboinflammation in COVID-19-associated pneumonia: A retrospective study #MMPMID34153649 Nieri D; Neri T; Barbieri G; Moneta S; Morelli G; Mingardi D; Spinelli S; Ghiadoni L; Falcone M; Tiseo G; Menichetti F; Franzini M; Caponi L; Paolicchi A; Pancani R; Pistelli F; Carrozzi L; Celi A Thromb Res 2021[Aug]; 204 (?): 88-94 PMID34153649show ga PURPOSE: A derangement of the coagulation process and thromboinflammatory events has emerged as pathologic characteristics of severe COVID-19, characterized by severe respiratory failure. CC motive chemokine ligand 2 (CCL2), a chemokine originally described as a chemotactic agent for monocytes, is involved in inflammation, coagulation activation and neoangiogenesis. We investigated the association of CCL2 levels with coagulation derangement and respiratory impairment in patients with COVID-19. METHODS: We retrospectively evaluated 281 patients admitted to two hospitals in Italy with COVID-19. Among them, CCL2 values were compared in different groups (identified according to D-dimer levels and the lowest PaO(2)/FiO(2) recorded during hospital stay, P/F(nadir)) by Jonckheere-Terpstra tests; linear regression analysis was used to analyse the relationship between CCL2 and P/F(nadir). We performed Mann-Whitney test and Kaplan-Meier curves to investigate the role of CCL2 according to different clinical outcomes (survival and endotracheal intubation [ETI]). RESULTS: CCL2 levels were progressively higher in patients with increasing D-dimer levels and with worse gas exchange impairment; there was a statistically significant linear correlation between log CCL2 and log P/F(nadir). CCL2 levels were significantly higher in patients with unfavourable clinical outcomes; Kaplan-Meier curves for the composite outcome death and/or need for ETI showed a significantly worse prognosis for patients with higher (> median) CCL2 levels. CONCLUSIONS: CCL2 correlates with both indices of activation of the coagulation cascade and respiratory impairment severity, which are likely closely related in COVID-19 pathology, thus suggesting that CCL2 could be involved in the thromboinflammatory events characterizing this disease. |*COVID-19[MESH] |*Thrombosis[MESH] |Chemokine CCL2[MESH] |Chemokines, CC[MESH] |Humans[MESH] |Inflammation[MESH] |Italy[MESH] |Ligands[MESH] |Retrospective Studies[MESH]C-C motive chemokine ligand 2 and thromboinflammation in COVID-19-asso(epmc).pdf DeepDyve Pubget Overpricing