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10.1016/j.micpath.2021.105057 http://scihub22266oqcxt.onion/10.1016/j.micpath.2021.105057 34153419!8215377!34153419     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Microb+Pathog 2021 ; 158 (ä): 105057 Nephropedia Template TP {{tp|p=34153419|t=2021. Potential biomarkers for the early prediction of SARS-COV-2 disease outcome |pdf=|usr=}}{{34153419}} gab.com Text Potential biomarkers for the early prediction of SARS-COV-2 disease outcome JO: Microb Pathog http://www.kidney.de/pget.php?&tw=1&pmid=34153419 #FOAvip The current pandemic due to the fast spreading of SARS-CoV-2 infection has caused severe impairment in health, social, economic, scientific, and medical sectors across the globe. Owing to the not so well understood mechanism of disease pathogenesis in terms of variations in immune responses, there remains obscure why some of the patients who are infected by the novel SARS-CoV-2 develop an unpredictable clinical course that rapidly causes severe and deadly complications/manifestations. Currently, several assays are available for the confirmation of SARS-CoV-2 infection at the point of care. However, none of these assays can predict the severity of the COVID-19 disease. Thus, the identification of a prognostic biomarker that forecasts the condition of SARS-CoV-2 patients to develop a severe form of the disease could enable the clinicians for more efficient patient triage and treatment. In this regard, the present review describes the role of selected biomolecules that are crucially involved in the immune-pathogenesis of SARS-CoV-2 infection such as hyper-immune responsiveness, bradykinin storm and vascular leakage assuming these may serve as an effective prognostic biomarker in COVID-19 to understand the outcome of the disease. Based on the review, we also propose the development of a cost-effective SERS-based prognostic biosensor for the detection and quantification of biomolecules for use as a point-of-care system during a disease outbreak. Twit Text FOAVip Potential biomarkers for the early prediction of SARS-COV-2 disease outcome ????Microb Pathog http://www.kidney.de/pget.php?&tw=1&pmid=34153419 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34153419 #FOAvip English Wikipedia <ref>{{Cite pmid|34153419}}</ref> Potential biomarkers for the early prediction of SARS-COV-2 disease outcome #MMPMID34153419 Mariappan V; Manoharan PS; R P; Shanmugam L; Rao SR; Pillai AB Microb Pathog 2021[Sep]; 158 (ä): 105057 PMID34153419show ga The current pandemic due to the fast spreading of SARS-CoV-2 infection has caused severe impairment in health, social, economic, scientific, and medical sectors across the globe. Owing to the not so well understood mechanism of disease pathogenesis in terms of variations in immune responses, there remains obscure why some of the patients who are infected by the novel SARS-CoV-2 develop an unpredictable clinical course that rapidly causes severe and deadly complications/manifestations. Currently, several assays are available for the confirmation of SARS-CoV-2 infection at the point of care. However, none of these assays can predict the severity of the COVID-19 disease. Thus, the identification of a prognostic biomarker that forecasts the condition of SARS-CoV-2 patients to develop a severe form of the disease could enable the clinicians for more efficient patient triage and treatment. In this regard, the present review describes the role of selected biomolecules that are crucially involved in the immune-pathogenesis of SARS-CoV-2 infection such as hyper-immune responsiveness, bradykinin storm and vascular leakage assuming these may serve as an effective prognostic biomarker in COVID-19 to understand the outcome of the disease. Based on the review, we also propose the development of a cost-effective SERS-based prognostic biosensor for the detection and quantification of biomolecules for use as a point-of-care system during a disease outbreak. |*COVID-19[MESH] |*SARS-CoV-2[MESH] |Biomarkers[MESH] |Humans[MESH]Potential biomarkers for the early prediction of SARS-COV-2 disease ou(epmc).pdf DeepDyve Pubget Overpricing