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suck abstract from ncbi


10.1007/s40121-021-00461-3

http://scihub22266oqcxt.onion/10.1007/s40121-021-00461-3
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suck abstract from ncbi

pmid34152573      Infect+Dis+Ther 2021 ; 10 (3): 1579-1590
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  • Long-Term Patient-Centred Follow-up in a Prospective Cohort of Patients with COVID-19 #MMPMID34152573
  • Righi E; Mirandola M; Mazzaferri F; Razzaboni E; Zaffagnini A; Erbogasto A; Vecchia ID; Auerbach N; Ivaldi F; Mongardi M; Minuz P; Milella M; Mehrabi S; Olivieri O; Girelli D; Polati E; Micheletto C; Tacconelli E
  • Infect Dis Ther 2021[Sep]; 10 (3): 1579-1590 PMID34152573show ga
  • INTRODUCTION: To better define COVID-19 long-term impact we prospectively analysed patient-centred outcomes, including general health and symptom duration. METHODS: Barthel index (BI), St. George's Respiratory Questionnaire adapted to patients with COVID-19 (aSGRQ) and WHO Clinical Progression Scale (CPS) were measured at enrolment and at 6 weeks from the onset of symptoms. Persistence of most frequently reported symptoms was assessed at 6 weeks and, among symptomatic patients, at 12 weeks from the onset of symptoms. Predictors of impaired general health over time were identified using an ordinal multilevel multivariate model. RESULTS: A total of 448 patients (55% men, median age 56 years) were enrolled. WHO-CPS showed mild, moderate and severe disease in 48%, 42% and 10% of patients at admission and mild disease in all patients at follow-up, respectively. BI and aSGRQ were normal in 96% and 93% patients before COVID-19 but only in 47% and 16% at COVID-19 diagnosis and in 87% and 65% at 6-week follow-up. Male gender was identified by all three assessments as a predictor of impaired general health (BI, OR 2.14, p < 0.0001; aSGRQ, OR 0.53, p = 0.003; WHO-CPS, OR 1.56, p = 0.01). Other predictors included age, ICU admission and comorbidities (e.g. cardiovascular disease and cancer) for BI, hospital admission for aSGRQ, age and presence of comorbidities for WHO-CPS. At 6- and 12-week follow-up, 39% and 20% of patients, respectively, were still reporting symptoms. Fatigue and breathlessness were the most frequently reported symptoms. CONCLUSIONS: Long-term follow-up facilitates the monitoring of health impairment and symptom persistence and can contribute to plan tailored interventions.
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