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10.7554/eLife.66522 http://scihub22266oqcxt.onion/10.7554/eLife.66522 34151773!8245129!34151773     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Elife 2021 ; 10 (ä): ä Nephropedia Template TP {{tp|p=34151773|t=2021. Ketogenic diet restrains aging-induced exacerbation of coronavirus infection in mice |pdf=|usr=}}{{34151773}} gab.com Text Ketogenic diet restrains aging-induced exacerbation of coronavirus infection in mice JO: Elife http://www.kidney.de/pget.php?&tw=1&pmid=34151773 #FOAvip Increasing age is the strongest predictor of risk of COVID-19 severity and mortality. Immunometabolic switch from glycolysis to ketolysis protects against inflammatory damage and influenza infection in adults. To investigate how age compromises defense against coronavirus infection, and whether a pro-longevity ketogenic diet (KD) impacts immune surveillance, we developed an aging model of natural murine beta coronavirus (mCoV) infection with mouse hepatitis virus strain-A59 (MHV-A59). When inoculated intranasally, mCoV is pneumotropic and recapitulates several clinical hallmarks of COVID-19 infection. Aged mCoV-A59-infected mice have increased mortality and higher systemic inflammation in the heart, adipose tissue, and hypothalamus, including neutrophilia and loss of gammadelta T cells in lungs. Activation of ketogenesis in aged mice expands tissue protective gammadelta T cells, deactivates the NLRP3 inflammasome, and decreases pathogenic monocytes in lungs of infected aged mice. These data establish harnessing of the ketogenic immunometabolic checkpoint as a potential treatment against coronavirus infection in the aged. Twit Text FOAVip Ketogenic diet restrains aging-induced exacerbation of coronavirus infection in mice ????Elife http://www.kidney.de/pget.php?&tw=1&pmid=34151773 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34151773 #FOAvip English Wikipedia <ref>{{Cite pmid|34151773}}</ref> Ketogenic diet restrains aging-induced exacerbation of coronavirus infection in mice #MMPMID34151773 Ryu S; Shchukina I; Youm YH; Qing H; Hilliard B; Dlugos T; Zhang X; Yasumoto Y; Booth CJ; Fernandez-Hernando C; Suarez Y; Khanna K; Horvath TL; Dietrich MO; Artyomov M; Wang A; Dixit VD Elife 2021[Jun]; 10 (ä): ä PMID34151773show ga Increasing age is the strongest predictor of risk of COVID-19 severity and mortality. Immunometabolic switch from glycolysis to ketolysis protects against inflammatory damage and influenza infection in adults. To investigate how age compromises defense against coronavirus infection, and whether a pro-longevity ketogenic diet (KD) impacts immune surveillance, we developed an aging model of natural murine beta coronavirus (mCoV) infection with mouse hepatitis virus strain-A59 (MHV-A59). When inoculated intranasally, mCoV is pneumotropic and recapitulates several clinical hallmarks of COVID-19 infection. Aged mCoV-A59-infected mice have increased mortality and higher systemic inflammation in the heart, adipose tissue, and hypothalamus, including neutrophilia and loss of gammadelta T cells in lungs. Activation of ketogenesis in aged mice expands tissue protective gammadelta T cells, deactivates the NLRP3 inflammasome, and decreases pathogenic monocytes in lungs of infected aged mice. These data establish harnessing of the ketogenic immunometabolic checkpoint as a potential treatment against coronavirus infection in the aged. |Age Factors[MESH] |Aging[MESH] |Animals[MESH] |COVID-19/diet therapy[MESH] |Coronavirus Infections/*diet therapy/metabolism/mortality[MESH] |Diet, Ketogenic/*methods[MESH] |Disease Models, Animal[MESH] |Glycolysis[MESH] |Humans[MESH] |Inflammasomes/metabolism[MESH] |Ketone Bodies/metabolism[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Murine hepatitis virus/metabolism/*pathogenicity[MESH] |NLR Family, Pyrin Domain-Containing 3 Protein/metabolism[MESH]Ketogenic diet restrains aging-induced exacerbation of coronavirus inf(epmc).pdf DeepDyve Pubget Overpricing