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10.1016/j.xcrm.2021.100329 http://scihub22266oqcxt.onion/10.1016/j.xcrm.2021.100329 34151306!8205277!34151306     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep+Med 2021 ; 2 (7): 100329 Nephropedia Template TP {{tp|p=34151306|t=2021. Serological analysis reveals an imbalanced IgG subclass composition associated with COVID-19 disease severity |pdf=|usr=}}{{34151306}} gab.com Text Serological analysis reveals an imbalanced IgG subclass composition associated with COVID-19 disease severity JO: Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=34151306 #FOAvip Coronavirus disease 2019 (COVID-19) is associated with a wide spectrum of disease presentation, ranging from asymptomatic infection to acute respiratory distress syndrome (ARDS). Paradoxically, a direct relationship has been suggested between COVID-19 disease severity and the levels of circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific antibodies, including virus-neutralizing titers. A serological analysis of 536 convalescent healthcare workers reveals that SARS-CoV-2-specific and virus-neutralizing antibody levels are elevated in individuals that experience severe disease. The severity-associated increase in SARS-CoV-2-specific antibody is dominated by immunoglobulin G (IgG), with an IgG subclass ratio skewed toward elevated receptor binding domain (RBD)- and S1-specific IgG3. In addition, individuals that experience severe disease show elevated SARS-CoV-2-specific antibody binding to the inflammatory receptor Fc?RIIIa. Based on these correlational studies, we propose that spike-specific IgG subclass utilization may contribute to COVID-19 disease severity through potent Fc-mediated effector functions. These results may have significant implications for SARS-CoV-2 vaccine design and convalescent plasma therapy. Twit Text FOAVip Serological analysis reveals an imbalanced IgG subclass composition associated with COVID-19 disease severity ????Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=34151306 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34151306 #FOAvip English Wikipedia <ref>{{Cite pmid|34151306}}</ref> Serological analysis reveals an imbalanced IgG subclass composition associated with COVID-19 disease severity #MMPMID34151306 Yates JL; Ehrbar DJ; Hunt DT; Girardin RC; Dupuis AP 2nd; Payne AF; Sowizral M; Varney S; Kulas KE; Demarest VL; Howard KM; Carson K; Hales M; Ejemel M; Li Q; Wang Y; Peredo-Wende R; Ramani A; Singh G; Strle K; Mantis NJ; McDonough KA; Lee WT Cell Rep Med 2021[Jul]; 2 (7): 100329 PMID34151306show ga Coronavirus disease 2019 (COVID-19) is associated with a wide spectrum of disease presentation, ranging from asymptomatic infection to acute respiratory distress syndrome (ARDS). Paradoxically, a direct relationship has been suggested between COVID-19 disease severity and the levels of circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific antibodies, including virus-neutralizing titers. A serological analysis of 536 convalescent healthcare workers reveals that SARS-CoV-2-specific and virus-neutralizing antibody levels are elevated in individuals that experience severe disease. The severity-associated increase in SARS-CoV-2-specific antibody is dominated by immunoglobulin G (IgG), with an IgG subclass ratio skewed toward elevated receptor binding domain (RBD)- and S1-specific IgG3. In addition, individuals that experience severe disease show elevated SARS-CoV-2-specific antibody binding to the inflammatory receptor Fc?RIIIa. Based on these correlational studies, we propose that spike-specific IgG subclass utilization may contribute to COVID-19 disease severity through potent Fc-mediated effector functions. These results may have significant implications for SARS-CoV-2 vaccine design and convalescent plasma therapy. |Adult[MESH] |Antibodies, Viral/*blood[MESH] |COVID-19/*blood[MESH] |Female[MESH] |Humans[MESH] |Immunoglobulin G/*blood[MESH] |Male[MESH] |Middle Aged[MESH] |SARS-CoV-2/immunology[MESH]Serological analysis reveals an imbalanced IgG subclass composition as(epmc).pdf DeepDyve Pubget Overpricing