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10.1016/j.synbio.2021.06.002 http://scihub22266oqcxt.onion/10.1016/j.synbio.2021.06.002 34151035!8200311!34151035     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34151035&cmd=llinks): Failed to open stream: HTTP request failed! 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Association between the nasopharyngeal microbiome and metabolome in patients with COVID-19 |pdf=|usr=}}{{34151035}} gab.com Text Association between the nasopharyngeal microbiome and metabolome in patients with COVID-19 JO: Synth Syst Biotechnol http://www.kidney.de/pget.php?&tw=1&pmid=34151035 #FOAvip SARS-CoV-2, the causative agent for COVID-19, infect human mainly via respiratory tract, which is heavily inhabited by local microbiota. However, the interaction between SARS-CoV-2 and nasopharyngeal microbiota, and the association with metabolome has not been well characterized. Here, metabolomic analysis of blood, urine, and nasopharyngeal swabs from a group of COVID-19 and non-COVID-19 patients, and metagenomic analysis of pharyngeal samples were used to identify the key features of COVID-19. Results showed lactic acid, l-proline, and chlorogenic acid methyl ester (CME) were significantly reduced in the sera of COVID-19 patients compared with non-COVID-19 ones. Nasopharyngeal commensal bacteria including Gemella morbillorum, Gemella haemolysans and Leptotrichia hofstadii were notably depleted in the pharynges of COVID-19 patients, while Prevotella histicola, Streptococcus sanguinis, and Veillonella dispar were relatively increased. The abundance of G. haemolysans and L. hofstadii were significantly positively associated with serum CME, which might be an anti-SARS-CoV-2 bacterial metabolite. This study provides important information to explore the linkage between nasopharyngeal microbiota and disease susceptibility. The findings were based on a very limited number of patients enrolled in this study; a larger size of cohort will be appreciated for further investigation. Twit Text FOAVip Association between the nasopharyngeal microbiome and metabolome in patients with COVID-19 ????Synth Syst Biotechnol http://www.kidney.de/pget.php?&tw=1&pmid=34151035 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34151035 #FOAvip English Wikipedia <ref>{{Cite pmid|34151035}}</ref> Association between the nasopharyngeal microbiome and metabolome in patients with COVID-19 #MMPMID34151035 Liu J; Liu S; Zhang Z; Lee X; Wu W; Huang Z; Lei Z; Xu W; Chen D; Wu X; Guo Y; Peng L; Lin B; Chong Y; Mou X; Shi M; Lan P; Chen T; Zhao W; Gao Z Synth Syst Biotechnol 2021[Sep]; 6 (3): 135-143 PMID34151035show ga SARS-CoV-2, the causative agent for COVID-19, infect human mainly via respiratory tract, which is heavily inhabited by local microbiota. However, the interaction between SARS-CoV-2 and nasopharyngeal microbiota, and the association with metabolome has not been well characterized. Here, metabolomic analysis of blood, urine, and nasopharyngeal swabs from a group of COVID-19 and non-COVID-19 patients, and metagenomic analysis of pharyngeal samples were used to identify the key features of COVID-19. Results showed lactic acid, l-proline, and chlorogenic acid methyl ester (CME) were significantly reduced in the sera of COVID-19 patients compared with non-COVID-19 ones. Nasopharyngeal commensal bacteria including Gemella morbillorum, Gemella haemolysans and Leptotrichia hofstadii were notably depleted in the pharynges of COVID-19 patients, while Prevotella histicola, Streptococcus sanguinis, and Veillonella dispar were relatively increased. The abundance of G. haemolysans and L. hofstadii were significantly positively associated with serum CME, which might be an anti-SARS-CoV-2 bacterial metabolite. This study provides important information to explore the linkage between nasopharyngeal microbiota and disease susceptibility. The findings were based on a very limited number of patients enrolled in this study; a larger size of cohort will be appreciated for further investigation. äAssociation between the nasopharyngeal microbiome and metabolome in pa(epmc).pdf DeepDyve Pubget Overpricing