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10.1155/2021/6657894

http://scihub22266oqcxt.onion/10.1155/2021/6657894
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34150910!8197671!34150910
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suck abstract from ncbi


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pmid34150910      J+Immunol+Res 2021 ; 2021 (ä): 6657894
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  • Analysis of Lymphocyte Subpopulations and Cytokines in COVID-19-Associated Pneumonia and Community-Acquired Pneumonia #MMPMID34150910
  • Liu G; Jiang X; Zeng X; Pan Y; Xu H
  • J Immunol Res 2021[]; 2021 (ä): 6657894 PMID34150910show ga
  • BACKGROUND: The 2019 novel coronavirus SARS-CoV-2 caused large outbreaks of COVID-19 worldwide. COVID-19 resembles community-acquired pneumonia (CAP). Our aim was to identify lymphocyte subpopulations to distinguish between COVID-19 and CAP. METHODS: We compared the peripheral blood lymphocytes and their subsets in 296 patients with COVID-19 and 130 patients with CAP. Parameters for independent prediction of COVID-19 were calculated by logistic regression. RESULTS: The main lymphocyte subpopulations (CD3(+)CD4(+), CD16(+)CD56(+), and CD4(+)/CD8(+) ratio) and cytokines (TNF-alpha and IFN-gamma) of COVID-19 patients were significantly different from that of CAP patients. CD16(+)CD56(+)%, CD4(+)/CD8(+)ratio, CD19(+), and CD3(+)CD4(+) were identified as predictors of COVID-19 diagnosis by logistic regression. In addition, the CD3(+)CD4(+)counts, CD3(+)CD8(+) counts, andTNF-alpha are independent predictors of disease severity in patients. CONCLUSIONS: Lymphopenia is an important part of SARS-CoV-2 infection, and lymphocyte subsets and cytokines may be useful to predict the severity and clinical outcomes of the disease.
  • |*CD4-CD8 Ratio[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |COVID-19 Testing[MESH]
  • |COVID-19/*blood/immunology/pathology[MESH]
  • |Community-Acquired Infections/microbiology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Interferon-gamma/*blood[MESH]
  • |Lymphocyte Subsets/*cytology/immunology[MESH]
  • |Lymphopenia/blood/pathology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pneumonia/*blood/immunology/pathology[MESH]
  • |Prognosis[MESH]
  • |SARS-CoV-2/immunology[MESH]
  • |Severity of Illness Index[MESH]


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