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10.3389/fmed.2021.670694 http://scihub22266oqcxt.onion/10.3389/fmed.2021.670694 34150806!8211892!34150806     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Med+(Lausanne) 2021 ; 8 (ä): 670694 Nephropedia Template TP {{tp|p=34150806|t=2021. Investigation of Coagulation Biomarkers to Assess Clinical Deterioration in SARS-CoV-2 Infection |pdf=|usr=}}{{34150806}} gab.com Text Investigation of Coagulation Biomarkers to Assess Clinical Deterioration in SARS-CoV-2 Infection JO: Front Med (Lausanne) http://www.kidney.de/pget.php?&tw=1&pmid=34150806 #FOAvip Since December 2019, a pandemic caused by a new coronavirus has spread to more than 170 countries around the world. Worsening infected patients requiring intensive care unit (ICU) admission associated with 30% of mortality. A part of worsening is induced by hemostasis deregulation. The aim of this study was to investigate the association of coagulation activation in COVID-19 progression. Thirty-five of the 99 patients got clinically worse. The final model of the logistic regression analysis revealed that O(2) requirement (RR = 7.27 [1.50-19.31]), monocytes below 0.2G/L (RR = 2.88 [1.67-3.19]), fibrinogen levels (RR = 1.45 [1.17-1.82] per g/L increase), prothrombin fragments 1+2 higher than 290 pM (RR = 2.39 [1.20-3.30]), and thrombin peak (RR = 1.28 [1.03-1.59] per 50 nM increase) were associated with an increased risk of clinical worsening. A fibrinogen level threshold of 5.5 g/L, a thrombin peak measurement threshold of 99 pM, and O(2) requirement associated with clinical outcome in more than 80% of our cohort. In conclusion, we identified fibrinogen and thrombin peak at admission as coagulation biomarkers associated with an increased risk of ICU admission or death. This finding allows initiating steroids and triage for worsening patients. Our results should therefore be considered as exploratory and deserve confirmation. Twit Text FOAVip Investigation of Coagulation Biomarkers to Assess Clinical Deterioration in SARS-CoV-2 Infection ????Front Med (Lausanne) http://www.kidney.de/pget.php?&tw=1&pmid=34150806 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34150806 #FOAvip English Wikipedia <ref>{{Cite pmid|34150806}}</ref> Investigation of Coagulation Biomarkers to Assess Clinical Deterioration in SARS-CoV-2 Infection #MMPMID34150806 Billoir P; Alexandre K; Duflot T; Roger M; Miranda S; Goria O; Joly LM; Demeyere M; Feugray G; Brunel V; Etienne M; Le Cam Duchez V Front Med (Lausanne) 2021[]; 8 (ä): 670694 PMID34150806show ga Since December 2019, a pandemic caused by a new coronavirus has spread to more than 170 countries around the world. Worsening infected patients requiring intensive care unit (ICU) admission associated with 30% of mortality. A part of worsening is induced by hemostasis deregulation. The aim of this study was to investigate the association of coagulation activation in COVID-19 progression. Thirty-five of the 99 patients got clinically worse. The final model of the logistic regression analysis revealed that O(2) requirement (RR = 7.27 [1.50-19.31]), monocytes below 0.2G/L (RR = 2.88 [1.67-3.19]), fibrinogen levels (RR = 1.45 [1.17-1.82] per g/L increase), prothrombin fragments 1+2 higher than 290 pM (RR = 2.39 [1.20-3.30]), and thrombin peak (RR = 1.28 [1.03-1.59] per 50 nM increase) were associated with an increased risk of clinical worsening. A fibrinogen level threshold of 5.5 g/L, a thrombin peak measurement threshold of 99 pM, and O(2) requirement associated with clinical outcome in more than 80% of our cohort. In conclusion, we identified fibrinogen and thrombin peak at admission as coagulation biomarkers associated with an increased risk of ICU admission or death. This finding allows initiating steroids and triage for worsening patients. Our results should therefore be considered as exploratory and deserve confirmation. äInvestigation of Coagulation Biomarkers to Assess Clinical Deteriorati(epmc).pdf DeepDyve Pubget Overpricing