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10.3389/fimmu.2021.668074 http://scihub22266oqcxt.onion/10.3389/fimmu.2021.668074 34149705!8208034!34149705     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2021 ; 12 (ä): 668074 Nephropedia Template TP {{tp|p=34149705|t=2021. Eosinophils and Chronic Respiratory Diseases in Hospitalized COVID-19 Patients |pdf=|usr=}}{{34149705}} gab.com Text Eosinophils and Chronic Respiratory Diseases in Hospitalized COVID-19 Patients JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34149705 #FOAvip BACKGROUND: Studies on the role of eosinophils in coronavirus disease 2019 (COVID-19) are scarce, though available findings suggest a possible association with disease severity. Our study analyzes the relationship between eosinophils and COVID-19, with a focus on disease severity and patients with underlying chronic respiratory diseases. METHODS: We performed a retrospective analysis of 3018 subjects attended at two public hospitals in Madrid (Spain) with PCR-confirmed SARS-CoV-2 infection from January 31 to April 17, 2020. Patients with eosinophil counts less than 0.02x10(9)/L were considered to have eosinopenia. Individuals with chronic respiratory diseases (n=384) were classified according to their particular underlying condition, i.e., asthma, chronic pulmonary obstructive disease, or obstructive sleep apnea. RESULTS: Of the 3018 patients enrolled, 479 were excluded because of lack of information at the time of admission. Of 2539 subjects assessed, 1396 patients presented an eosinophil count performed on admission, revealing eosinopenia in 376 cases (26.93%). Eosinopenia on admission was associated with a higher risk of intensive care unit (ICU) or respiratory intensive care unit (RICU) admission (OR:2.21; 95%CI:1.42-3.45; p<0.001) but no increased risk of mortality (p>0.05). CONCLUSIONS: Eosinopenia on admission conferred a higher risk of severe disease (requiring ICU/RICU care), but was not associated with increased mortality. In patients with chronic respiratory diseases who develop COVID-19, age seems to be the main risk factor for progression to severe disease or death. Twit Text FOAVip Eosinophils and Chronic Respiratory Diseases in Hospitalized COVID-19 Patients ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34149705 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34149705 #FOAvip English Wikipedia <ref>{{Cite pmid|34149705}}</ref> Eosinophils and Chronic Respiratory Diseases in Hospitalized COVID-19 Patients #MMPMID34149705 Valverde-Monge M; Canas JA; Barroso B; Betancor D; Ortega-Martin L; Gomez-Lopez A; Rodriguez-Nieto MJ; Mahillo-Fernandez I; Sastre J; Del Pozo V Front Immunol 2021[]; 12 (ä): 668074 PMID34149705show ga BACKGROUND: Studies on the role of eosinophils in coronavirus disease 2019 (COVID-19) are scarce, though available findings suggest a possible association with disease severity. Our study analyzes the relationship between eosinophils and COVID-19, with a focus on disease severity and patients with underlying chronic respiratory diseases. METHODS: We performed a retrospective analysis of 3018 subjects attended at two public hospitals in Madrid (Spain) with PCR-confirmed SARS-CoV-2 infection from January 31 to April 17, 2020. Patients with eosinophil counts less than 0.02x10(9)/L were considered to have eosinopenia. Individuals with chronic respiratory diseases (n=384) were classified according to their particular underlying condition, i.e., asthma, chronic pulmonary obstructive disease, or obstructive sleep apnea. RESULTS: Of the 3018 patients enrolled, 479 were excluded because of lack of information at the time of admission. Of 2539 subjects assessed, 1396 patients presented an eosinophil count performed on admission, revealing eosinopenia in 376 cases (26.93%). Eosinopenia on admission was associated with a higher risk of intensive care unit (ICU) or respiratory intensive care unit (RICU) admission (OR:2.21; 95%CI:1.42-3.45; p<0.001) but no increased risk of mortality (p>0.05). CONCLUSIONS: Eosinopenia on admission conferred a higher risk of severe disease (requiring ICU/RICU care), but was not associated with increased mortality. In patients with chronic respiratory diseases who develop COVID-19, age seems to be the main risk factor for progression to severe disease or death. |*Eosinophils/immunology[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |COVID-19/*blood/immunology[MESH] |Chronic Disease[MESH] |Female[MESH] |Hospitalization[MESH] |Humans[MESH] |Leukocyte Count[MESH] |Lung Diseases/*epidemiology[MESH] |Male[MESH] |Middle Aged[MESH] |Prevalence[MESH] |Retrospective Studies[MESH] |Risk Factors[MESH] |SARS-CoV-2[MESH]Eosinophils and Chronic Respiratory Diseases in Hospitalized COVID-19 (epmc).pdf DeepDyve Pubget Overpricing