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Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Clin+Immunol 2021 ; 229 (ä): 108786 Nephropedia Template TP
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Neurologic adverse events among 704,003 first-dose recipients of the BNT162b2 mRNA COVID-19 vaccine in Mexico: A nationwide descriptive study #MMPMID34147649
Garcia-Grimshaw M; Ceballos-Liceaga SE; Hernandez-Vanegas LE; Nunez I; Hernandez-Valdivia N; Carrillo-Garcia DA; Michel-Chavez A; Galnares-Olalde JA; Carbajal-Sandoval G; Del Mar Saniger-Alba M; Carrillo-Mezo RA; Fragoso-Saavedra S; Espino-Ojeda A; Blaisdell-Vidal C; Mosqueda-Gomez JL; Sierra-Madero J; Perez-Padilla R; Alomia-Zegarra JL; Lopez-Gatell H; Diaz-Ortega JL; Reyes-Teran G; Arauz A; Valdes-Ferrer SI
Clin Immunol 2021[Aug]; 229 (ä): 108786 PMID34147649show ga
mRNA vaccines against SARS-CoV-2 are remarkably effective. Limited information exists about the incidence of adverse events following immunization (AEFI) with their use. We conducted a prospective observational study including data from 704,003 first-doses recipients; 6536 AEFI were reported, of whom 65.1% had at least one neurologic AEFI (non-serious 99.6%). Thirty-three serious events were reported; 17 (51.5%) were neurologic (observed frequency, 2.4/100,000 doses). At the time of writing this report, 16/17 cases had been discharged without deaths. Our data suggest that the BNT162b2 mRNA COVID-19 vaccine is safe; its individual and societal benefits outweigh the low percentage of serious neurologic AEFI. This information should help to dissipate hesitancy towards this new vaccine platform.