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10.1016/j.celrep.2021.109320 http://scihub22266oqcxt.onion/10.1016/j.celrep.2021.109320 34146478!8192958!34146478     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2021 ; 35 (13): 109320 Nephropedia Template TP {{tp|p=34146478|t=2021. Memory B cells targeting SARS-CoV-2 spike protein and their dependence on CD4(+) T cell help |pdf=|usr=}}{{34146478}} gab.com Text Memory B cells targeting SARS-CoV-2 spike protein and their dependence on CD4(+) T cell help JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=34146478 #FOAvip Memory B cells seem to be more durable than antibodies and thus crucial for the long-term immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Here we investigate SARS-CoV-2 spike-specific memory B cells and their dependence on CD4(+) T cell help in different settings of coronavirus disease 2019 (COVID-19). Compared with severely ill individuals, those who recovered from mild COVID-19 develop fewer but functionally superior spike-specific memory B cells. Generation and affinity maturation of these cells is best associated with IL-21(+)CD4(+) T cells in recovered individuals and CD40L(+)CD4(+) T cells in severely ill individuals. The increased activation and exhaustion of memory B cells observed during COVID-19 correlates with CD4(+) T cell functions. Intriguingly, CD4(+) T cells recognizing membrane protein show a stronger association with spike-specific memory B cells than those recognizing spike or nucleocapsid proteins. Overall, we identify CD4(+) T cell subsets associated with the generation of B cell memory during SARS-CoV-2 infection. Twit Text FOAVip Memory B cells targeting SARS-CoV-2 spike protein and their dependence on CD4(+) T cell help ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=34146478 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34146478 #FOAvip English Wikipedia <ref>{{Cite pmid|34146478}}</ref> Memory B cells targeting SARS-CoV-2 spike protein and their dependence on CD4(+) T cell help #MMPMID34146478 Pusnik J; Richter E; Schulte B; Dolscheid-Pommerich R; Bode C; Putensen C; Hartmann G; Alter G; Streeck H Cell Rep 2021[Jun]; 35 (13): 109320 PMID34146478show ga Memory B cells seem to be more durable than antibodies and thus crucial for the long-term immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Here we investigate SARS-CoV-2 spike-specific memory B cells and their dependence on CD4(+) T cell help in different settings of coronavirus disease 2019 (COVID-19). Compared with severely ill individuals, those who recovered from mild COVID-19 develop fewer but functionally superior spike-specific memory B cells. Generation and affinity maturation of these cells is best associated with IL-21(+)CD4(+) T cells in recovered individuals and CD40L(+)CD4(+) T cells in severely ill individuals. The increased activation and exhaustion of memory B cells observed during COVID-19 correlates with CD4(+) T cell functions. Intriguingly, CD4(+) T cells recognizing membrane protein show a stronger association with spike-specific memory B cells than those recognizing spike or nucleocapsid proteins. Overall, we identify CD4(+) T cell subsets associated with the generation of B cell memory during SARS-CoV-2 infection. |Antibodies, Viral/immunology[MESH] |B-Lymphocytes/*immunology[MESH] |CD4-Positive T-Lymphocytes/*immunology[MESH] |CD40 Ligand/immunology/metabolism[MESH] |COVID-19/*immunology[MESH] |Cross Reactions[MESH] |Humans[MESH] |Immunologic Memory[MESH] |Interleukins/immunology/metabolism[MESH] |SARS-CoV-2/*immunology[MESH]Memory B cells targeting SARS-CoV-2 spike protein and their dependence(epmc).pdf DeepDyve Pubget Overpricing