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10.1002/tcr.202100125 http://scihub22266oqcxt.onion/10.1002/tcr.202100125 34145723!8441866!34145723     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34145723&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Chem+Rec 2021 ; 21 (11): 3087-3101 Nephropedia Template TP {{tp|p=34145723|t=2021. From Cancer to COVID-19: A Perspective on Targeting Heparan Sulfate-Protein Interactions |pdf=|usr=}}{{34145723}} gab.com Text From Cancer to COVID-19: A Perspective on Targeting Heparan Sulfate-Protein Interactions JO: Chem Rec http://www.kidney.de/pget.php?&tw=1&pmid=34145723 #FOAvip Heparan sulfate (HS) is a complex, polyanionic polysaccharide ubiquitously expressed on cell surfaces and in the extracellular matrix. HS interacts with numerous proteins to mediate a vast array of biological and pathological processes. Inhibition of HS-protein interactions is thus an attractive approach for new therapeutic development for cancer and infectious diseases, including COVID-19; however, synthesis of well-defined native HS oligosaccharides remains challenging. This has aroused significant interest in the development of HS mimetics which are more synthetically tractable and have fewer side effects, such as undesired anticoagulant activity. This account provides a perspective on the design and synthesis of different classes of HS mimetics with useful properties, and the development of various assays and molecular modelling tools to progress our understanding of their interactions with HS-binding proteins. Twit Text FOAVip From Cancer to COVID-19: A Perspective on Targeting Heparan Sulfate-Protein Interactions ????Chem Rec http://www.kidney.de/pget.php?&tw=1&pmid=34145723 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34145723 #FOAvip English Wikipedia <ref>{{Cite pmid|34145723}}</ref> From Cancer to COVID-19: A Perspective on Targeting Heparan Sulfate-Protein Interactions #MMPMID34145723 Chhabra M; Doherty GG; See NW; Gandhi NS; Ferro V Chem Rec 2021[Nov]; 21 (11): 3087-3101 PMID34145723show ga Heparan sulfate (HS) is a complex, polyanionic polysaccharide ubiquitously expressed on cell surfaces and in the extracellular matrix. HS interacts with numerous proteins to mediate a vast array of biological and pathological processes. Inhibition of HS-protein interactions is thus an attractive approach for new therapeutic development for cancer and infectious diseases, including COVID-19; however, synthesis of well-defined native HS oligosaccharides remains challenging. This has aroused significant interest in the development of HS mimetics which are more synthetically tractable and have fewer side effects, such as undesired anticoagulant activity. This account provides a perspective on the design and synthesis of different classes of HS mimetics with useful properties, and the development of various assays and molecular modelling tools to progress our understanding of their interactions with HS-binding proteins. |*COVID-19[MESH] |*Neoplasms/drug therapy[MESH] |Heparitin Sulfate[MESH] |Humans[MESH] |Proteins[MESH]From Cancer to COVID-19: A Perspective on Targeting Heparan Sulfate-Pr(epmc).pdf DeepDyve Pubget Overpricing