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10.1016/j.medcli.2021.03.034

http://scihub22266oqcxt.onion/10.1016/j.medcli.2021.03.034
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suck abstract from ncbi


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pmid34144801      Med+Clin+(Barc) 2022 ; 158 (6): 265-269
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  • Plasma D-dimer value corrected by inflammatory markers in patients with SARS-CoV-2 infection: Its prognostic value in the diagnosis of venous thromboembolism #MMPMID34144801
  • Rueda-Camino JA; Sendin-Martin V; Joya-Seijo MD; Angelina-Garcia M; Zamarro-Garcia C; Gimena-Rodriguez FJ; Barba-Martin R
  • Med Clin (Barc) 2022[Mar]; 158 (6): 265-269 PMID34144801show ga
  • INTRODUCTION: D-dimer levels are elevated in COVID 19 and they correlate to the levels of other inflammatory markers such us ferritin, fibrinogen and C-reactive protein. It may be possible to correct D-dimer value in function of inflammatory markers, thus identifying patients at higher risk of venous thromboembolism (VTE). Our objectives are estimating a corrected value of plasma D-dimer as a linear function of ferritin, C-reactive protein and fibrinogen and stablishing a cut-off point of high probability of VTE. PATIENTS AND METHODS: Age and sex matched case-control study of all patients diagnosed with COVID 19 and VTE between March and May 2020 in a tertiary hospital in Madrid (Spain). Using linear regression, the best predictive model will be estimated and residual D-dimer values will be obtained and analyzed using ROC curves to determine its discriminative performance. RESULTS: Thirty-eight cases and seventy-six controls were included. There was 63.2% of men and mean age was 68.2. D-dimer was best predicted by a linear model including fibrinogen, ferritin and C-reactive protein. Using residual values, the optimal cutoff point was 2165ng/mL, with a sensitivity of 57.9% and specificity of 98.7%. CONCLUSION: It is possible to estimate a D-dimer corrected value in function of ferritin, C-reactive protein and fibrinogen. Using the observed and estimated value we can obtain a residual value that performs well as a screening method to detect patients who would benefit for further VTE diagnostic testing.
  • |*COVID-19/complications/diagnosis[MESH]
  • |*Venous Thromboembolism/diagnosis/etiology[MESH]
  • |Aged[MESH]
  • |Biomarkers[MESH]
  • |Case-Control Studies[MESH]
  • |Fibrin Fibrinogen Degradation Products[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Prognosis[MESH]


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