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10.1038/s41467-021-24063-2 http://scihub22266oqcxt.onion/10.1038/s41467-021-24063-2 34140503!8211686!34140503     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2021 ; 12 (1): 3683 Nephropedia Template TP {{tp|p=34140503|t=2021. Importance of the renal ion channel TRPM6 in the circadian secretion of renin to raise blood pressure |pdf=|usr=}}{{34140503}} gab.com Text Importance of the renal ion channel TRPM6 in the circadian secretion of renin to raise blood pressure JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34140503 #FOAvip Blood pressure has a daily pattern, with higher values in the active period. Its elevation at the onset of the active period substantially increases the risk of fatal cardiovascular events. Renin secretion stimulated by renal sympathetic neurons is considered essential to this process; however, its regulatory mechanism remains largely unknown. Here, we show the importance of transient receptor potential melastatin-related 6 (TRPM6), a Mg(2+)-permeable cation channel, in augmenting renin secretion in the active period. TRPM6 expression is significantly reduced in the distal convoluted tubule of hypotensive Cnnm2-deficient mice. We generate kidney-specific Trpm6-deficient mice and observe a decrease in blood pressure and a disappearance of its circadian variation. Consistently, renin secretion is not augmented in the active period. Furthermore, renin secretion after pharmacological activation of beta-adrenoreceptor, the target of neuronal stimulation, is abrogated, and the receptor expression is decreased in renin-secreting cells. These results indicate crucial roles of TRPM6 in the circadian regulation of blood pressure. Twit Text FOAVip Importance of the renal ion channel TRPM6 in the circadian secretion of renin to raise blood pressure ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34140503 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34140503 #FOAvip English Wikipedia <ref>{{Cite pmid|34140503}}</ref> Importance of the renal ion channel TRPM6 in the circadian secretion of renin to raise blood pressure #MMPMID34140503 Funato Y; Yamazaki D; Okuzaki D; Yamamoto N; Miki H Nat Commun 2021[Jun]; 12 (1): 3683 PMID34140503show ga Blood pressure has a daily pattern, with higher values in the active period. Its elevation at the onset of the active period substantially increases the risk of fatal cardiovascular events. Renin secretion stimulated by renal sympathetic neurons is considered essential to this process; however, its regulatory mechanism remains largely unknown. Here, we show the importance of transient receptor potential melastatin-related 6 (TRPM6), a Mg(2+)-permeable cation channel, in augmenting renin secretion in the active period. TRPM6 expression is significantly reduced in the distal convoluted tubule of hypotensive Cnnm2-deficient mice. We generate kidney-specific Trpm6-deficient mice and observe a decrease in blood pressure and a disappearance of its circadian variation. Consistently, renin secretion is not augmented in the active period. Furthermore, renin secretion after pharmacological activation of beta-adrenoreceptor, the target of neuronal stimulation, is abrogated, and the receptor expression is decreased in renin-secreting cells. These results indicate crucial roles of TRPM6 in the circadian regulation of blood pressure. |Adrenergic beta-Agonists/pharmacology[MESH] |Animals[MESH] |Blood Pressure/genetics/*physiology[MESH] |Cation Transport Proteins/deficiency/genetics[MESH] |Cell Line[MESH] |Circadian Rhythm/genetics/physiology[MESH] |Down-Regulation[MESH] |Female[MESH] |Gene Expression Regulation/genetics[MESH] |Homeostasis[MESH] |Isoproterenol/pharmacology[MESH] |Kidney Tubules, Distal/*metabolism[MESH] |Kidney/*metabolism/pathology[MESH] |Magnesium/metabolism[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Oligonucleotide Array Sequence Analysis[MESH] |RNA Interference[MESH] |Renin/*metabolism[MESH] |TRPM Cation Channels/deficiency/genetics/*metabolism[MESH]Importance of the renal ion channel TRPM6 in the circadian secretion o(epmc).pdf DeepDyve Pubget Overpricing