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10.1016/j.ijid.2021.06.022

http://scihub22266oqcxt.onion/10.1016/j.ijid.2021.06.022
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34139370!ä!34139370

suck abstract from ncbi


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pmid34139370      Int+J+Infect+Dis 2021 ; 108 (ä): 557-567
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  • Situational analysis of 10 countries with a high burden of drug-resistant tuberculosis 2 years post-UNHLM declaration: progress and setbacks in a changing landscape #MMPMID34139370
  • Monedero-Recuero I; Gegia M; Wares DF; Chadha SS; Mirzayev F
  • Int J Infect Dis 2021[Jul]; 108 (ä): 557-567 PMID34139370show ga
  • OBJECTIVES: Globally, drug-resistant tuberculosis (DR-TB) is the leading cause of death globally related to antimicrobial resistance, affecting 500,000 emergent cases annually. In 2018, the first United Nations High-Level Meeting (UNHLM) on tuberculosis declared DR-TB a global public health priority. Bold country targets were established for 2018-2022. This study reviews the DR-TB situation in 2018, and the UNHLM target accomplishments in 10 high-burden countries (HBCs). METHODS: An ecological descriptive analysis of the top 10 DR-TB HBCs (Bangladesh, China, India, Indonesia, Myanmar, Nigeria, Pakistan, Philippines, Russian Federation, and South Africa), which share 70% of the global DR-TB burden, was undertaken, complemented by a cascade-of-care analysis and a survey gathering additional information on key advances and setbacks 2 years after the UNHLM declaration. RESULTS: Most countries are showing historic advances and are on track for the 2018 and 2019 targets. However, according to the cascade-of-care, none of the countries are capable of providing effective care for 50% of the estimated patients. Increasing levels of fluoroquinolone resistance and access to timely susceptibility testing can jeopardize ongoing adoption of shorter, all-oral treatment regimens. The programmatic management of DR-TB in children remains minimal. Achievements for 2020 and beyond may be affected significantly by the coronavirus disease 2019 (COVID-19) pandemic. CONCLUSION: Triggered by the COVID-19 pandemic, there is a global risk of recoil in DR-TB care with long-term consequences in terms of deaths, suffering and wider transmission. Investment to support DR-TB services is more important now than ever to meet the aspirations of the UNHLM declaration.
  • |*COVID-19[MESH]
  • |*Tuberculosis, Multidrug-Resistant/drug therapy/epidemiology[MESH]
  • |*Tuberculosis/drug therapy/epidemiology[MESH]
  • |Antitubercular Agents/pharmacology/therapeutic use[MESH]
  • |Child[MESH]
  • |Humans[MESH]
  • |Pandemics[MESH]
  • |SARS-CoV-2[MESH]


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