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10.1007/s40121-021-00471-1

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suck abstract from ncbi


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pmid34137001      Infect+Dis+Ther 2021 ; 10 (3): 1081-1095
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  • The Role of Macrolides for the Management of Community-Acquired Pneumonia and Pneumonia by the Novel Coronavirus SARS-CoV-2 (COVID-19): A Position Paper by Four Medical Societies from Greece #MMPMID34137001
  • Giamarellos-Bourboulis EJ; Daikos GL; Gargalianos P; Gogos C; Lazanas M; Panagopoulos P; Poulakou G; Sambatakou H; Samarkos M
  • Infect Dis Ther 2021[Sep]; 10 (3): 1081-1095 PMID34137001show ga
  • In light of the accumulating evidence for survival benefit coming from the use of macrolides for community-acquired pneumonia (CAP), a group of experts from the field of internal medicine and infectious diseases frame a position statement on the use of macrolides for the management of bacterial CAP and for infection by the novel coronavirus (COVID-19). The statement is framed taking into consideration existing publications and own research experience. The main content of this statement is that the combination of one beta-lactam and a macrolide should be the first treatment of choice for patients with severe bacterial CAP. Severity is assessed as scoring 2 or more points on the CURB65 scoring system of severity or as pneumonia severity index III to V or C-reactive protein more than 150 mg/l; the suggested macrolide is either azithromycin or clarithromycin. The experts also suggest that in COVID-19 pneumonia, the combination of one beta-lactam and a macrolide should be reserved only when there is strong suspicion of bacterial co-infection.
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