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10.1021/acsptsci.0c00221 http://scihub22266oqcxt.onion/10.1021/acsptsci.0c00221 34136758!8043206!34136758     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Pharmacol+Transl+Sci 2021 ; 4 (3): 1124-1135 Nephropedia Template TP {{tp|p=34136758|t=2021. Discovery of TMPRSS2 Inhibitors from Virtual Screening as a Potential Treatment of COVID-19 |pdf=|usr=}}{{34136758}} gab.com Text Discovery of TMPRSS2 Inhibitors from Virtual Screening as a Potential Treatment of COVID-19 JO: ACS Pharmacol Transl Sci http://www.kidney.de/pget.php?&tw=1&pmid=34136758 #FOAvip The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has prompted researchers to pivot their efforts to finding antiviral compounds and vaccines. In this study, we focused on the human host cell transmembrane protease serine 2 (TMPRSS2), which plays an important role in the viral life cycle by cleaving the spike protein to initiate membrane fusion. TMPRSS2 is an attractive target and has received attention for the development of drugs against SARS and Middle East respiratory syndrome. Starting with comparative structural modeling and a binding model analysis, we developed an efficient pharmacophore-based approach and applied a large-scale in silico database screening for small-molecule inhibitors against TMPRSS2. The hits were evaluated in the TMPRSS2 biochemical assay and the SARS-CoV-2 pseudotyped particle entry assay. A number of novel inhibitors were identified, providing starting points for the further development of drug candidates for the treatment of coronavirus disease 2019. Twit Text FOAVip Discovery of TMPRSS2 Inhibitors from Virtual Screening as a Potential Treatment of COVID-19 ????ACS Pharmacol Transl Sci http://www.kidney.de/pget.php?&tw=1&pmid=34136758 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34136758 #FOAvip English Wikipedia <ref>{{Cite pmid|34136758}}</ref> Discovery of TMPRSS2 Inhibitors from Virtual Screening as a Potential Treatment of COVID-19 #MMPMID34136758 Hu X; Shrimp JH; Guo H; Xu M; Chen CZ; Zhu W; Zakharov AV; Jain S; Shinn P; Simeonov A; Hall MD; Shen M ACS Pharmacol Transl Sci 2021[Jun]; 4 (3): 1124-1135 PMID34136758show ga The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has prompted researchers to pivot their efforts to finding antiviral compounds and vaccines. In this study, we focused on the human host cell transmembrane protease serine 2 (TMPRSS2), which plays an important role in the viral life cycle by cleaving the spike protein to initiate membrane fusion. TMPRSS2 is an attractive target and has received attention for the development of drugs against SARS and Middle East respiratory syndrome. Starting with comparative structural modeling and a binding model analysis, we developed an efficient pharmacophore-based approach and applied a large-scale in silico database screening for small-molecule inhibitors against TMPRSS2. The hits were evaluated in the TMPRSS2 biochemical assay and the SARS-CoV-2 pseudotyped particle entry assay. A number of novel inhibitors were identified, providing starting points for the further development of drug candidates for the treatment of coronavirus disease 2019. äDiscovery of TMPRSS2 Inhibitors from Virtual Screening as a Potential (epmc).pdf DeepDyve Pubget Overpricing