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10.3389/fcell.2021.664868 http://scihub22266oqcxt.onion/10.3389/fcell.2021.664868 34136484!8201778!34136484     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Cell+Dev+Biol 2021 ; 9 (ä): 664868 Nephropedia Template TP {{tp|p=34136484|t=2021. SARS-CoV-2 Causes Acute Kidney Injury by Directly Infecting Renal Tubules |pdf=|usr=}}{{34136484}} gab.com Text SARS-CoV-2 Causes Acute Kidney Injury by Directly Infecting Renal Tubules JO: Front Cell Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=34136484 #FOAvip Acute kidney injury (AKI) is one of the most prevalent complications among hospitalized coronavirus disease 2019 (COVID-19) patients. Here, we aim to investigate the causes, risk factors, and outcomes of AKI in COVID-19 patients. We found that angiotensin-converting enzyme II (ACE2) and transmembrane protease serine 2 (TMPRSS2) were mainly expressed by different cell types in the human kidney. However, in autopsy kidney samples, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleoprotein was detected in ACE2(+) or TMPRSS2(+) renal tubular cells, whereas the RNAscope((R)) Assay targeting the SARS-CoV-2 Spike gene was positive mainly in the distal tubular cells and seldom in the proximal tubular cells. In addition, the TMPRSS2 and kidney injury marker protein levels were significantly higher in the SARS-CoV-2-infected renal distal tubular cells, indicating that SARS-CoV-2-mediated AKI mainly occurred in the renal distal tubular cells. Subsequently, a cohort analysis of 722 patients with COVID-19 demonstrated that AKI was significantly related to more serious disease stages and poor prognosis of COVID-19 patients. The progressive increase of blood urea nitrogen (BUN) level during the course of COVID-19 suggests that the patient's condition is aggravated. These results will greatly increase the current understanding of SARS-CoV-2 infection. Twit Text FOAVip SARS-CoV-2 Causes Acute Kidney Injury by Directly Infecting Renal Tubules ????Front Cell Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=34136484 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34136484 #FOAvip English Wikipedia <ref>{{Cite pmid|34136484}}</ref> SARS-CoV-2 Causes Acute Kidney Injury by Directly Infecting Renal Tubules #MMPMID34136484 Chen Z; Hu J; Liu L; Chen R; Wang M; Xiong M; Li ZQ; Zhao Y; Li H; Guan C; Zhang J; Liu L; Chen K; Wang YM Front Cell Dev Biol 2021[]; 9 (ä): 664868 PMID34136484show ga Acute kidney injury (AKI) is one of the most prevalent complications among hospitalized coronavirus disease 2019 (COVID-19) patients. Here, we aim to investigate the causes, risk factors, and outcomes of AKI in COVID-19 patients. We found that angiotensin-converting enzyme II (ACE2) and transmembrane protease serine 2 (TMPRSS2) were mainly expressed by different cell types in the human kidney. However, in autopsy kidney samples, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleoprotein was detected in ACE2(+) or TMPRSS2(+) renal tubular cells, whereas the RNAscope((R)) Assay targeting the SARS-CoV-2 Spike gene was positive mainly in the distal tubular cells and seldom in the proximal tubular cells. In addition, the TMPRSS2 and kidney injury marker protein levels were significantly higher in the SARS-CoV-2-infected renal distal tubular cells, indicating that SARS-CoV-2-mediated AKI mainly occurred in the renal distal tubular cells. Subsequently, a cohort analysis of 722 patients with COVID-19 demonstrated that AKI was significantly related to more serious disease stages and poor prognosis of COVID-19 patients. The progressive increase of blood urea nitrogen (BUN) level during the course of COVID-19 suggests that the patient's condition is aggravated. These results will greatly increase the current understanding of SARS-CoV-2 infection. äSARS-CoV-2 Causes Acute Kidney Injury by Directly Infecting Renal Tubu(epmc).pdf DeepDyve Pubget Overpricing