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10.12688/f1000research.36396.3

http://scihub22266oqcxt.onion/10.12688/f1000research.36396.3
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34136130!8182694!34136130
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suck abstract from ncbi


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pmid34136130      F1000Res 2021 ; 10 (ä): 64
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  • Association between convalescent plasma and the risk of mortality among patients with COVID-19: a meta-analysis #MMPMID34136130
  • Wardhani SO; Fajar JK; Wulandari L; Soegiarto G; Purnamasari Y; Asmiragani A; Maliga HA; Ilmawan M; Seran G; Iskandar DS; Ndapa CE; Hamat V; Wahyuni RA; Cyntia LOS; Maarang FM; Beo YA; Adar OA; Rakhmadhan IM; Shantikaratri ET; Putri ASD; Wahdini R; Broto EP; Suwanto AW; Tamara F; Mahendra AI; Winoto ES; Krisna PA; Harapan H
  • F1000Res 2021[]; 10 (ä): 64 PMID34136130show ga
  • Background: Convalescent plasma (CCP) has been used for treating some infectious diseases; however, the efficacy of CCP in coronavirus disease 2019 (COVID-19) remains controversial. The aim of this research was to assess the efficacy of CCP as an adjunctive treatment in COVID-19 patients. Methods: Embase, PubMed, Web of Science, Cochrane and MedRix were searched for potentially relevant articles. All included papers were assessed for the quality using modified Jadad scale and Newcastle-Ottawa scale for randomized controlled trial (RCT) and non - RCT, respectively. We used a Q test and Egger test to assess the heterogeneity and publication bias among studies, respectively. Mortality rates between patients treated with standard treatment and standard treatment with CCP were compared using a Z test. Results: A total of 12 papers consisting of three cross-sectional studies, one prospective study, five retrospective studies, and three RCT studies were included in our analysis. Of them, a total of 1,937 patients treated with CCP and 3,405 patients without CCP were included. The risk of mortality was 1.92-fold higher in patients without CCP compared to patients treated with CCP (OR: 1.92; 95%CI: 1.33, 2.77; p=0.0005). In severe COVID-19 sub-group analysis, we found that patients without CCP had a 1.32 times higher risk of mortality than those treated with CCP (OR: 1.32; 95%CI: 1.09, 1.60; p=0.0040). Conclusions: CCP, as adjunctive therapy, could reduce the mortality rate among COVID-19 patients.
  • |*COVID-19/therapy[MESH]
  • |*Coronavirus Infections[MESH]
  • |COVID-19 Serotherapy[MESH]
  • |Humans[MESH]
  • |Immunization, Passive[MESH]
  • |SARS-CoV-2[MESH]


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