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10.3389/fimmu.2021.666163 http://scihub22266oqcxt.onion/10.3389/fimmu.2021.666163 34135895!8202013!34135895     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2021 ; 12 (ä): 666163 Nephropedia Template TP {{tp|p=34135895|t=2021. Transcriptomic Signature Differences Between SARS-CoV-2 and Influenza Virus Infected Patients |pdf=|usr=}}{{34135895}} gab.com Text Transcriptomic Signature Differences Between SARS-CoV-2 and Influenza Virus Infected Patients JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34135895 #FOAvip The reason why most individuals with COVID-19 have relatively limited symptoms while other develop respiratory distress with life-threatening complications remains unknown. Increasing evidence suggests that COVID-19 associated adverse outcomes mainly rely on dysregulated immunity. Here, we compared transcriptomic profiles of blood cells from 103 patients with different severity levels of COVID-19 with that of 27 healthy and 22 influenza-infected individuals. Data provided a complete overview of SARS-CoV-2-induced immune signature, including a dramatic defect in IFN responses, a reduction of toxicity-related molecules in NK cells, an increased degranulation of neutrophils, a dysregulation of T cells, a dramatic increase in B cell function and immunoglobulin production, as well as an important over-expression of genes involved in metabolism and cell cycle in patients infected with SARS-CoV-2 compared to those infected with influenza viruses. These features also differed according to COVID-19 severity. Overall and specific gene expression patterns across groups can be visualized on an interactive website (https://bix.unil.ch/covid/). Collectively, these transcriptomic host responses to SARS-CoV-2 infection are discussed in the context of current studies, thereby improving our understanding of COVID-19 pathogenesis and shaping the severity level of COVID-19. Twit Text FOAVip Transcriptomic Signature Differences Between SARS-CoV-2 and Influenza Virus Infected Patients ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34135895 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34135895 #FOAvip English Wikipedia <ref>{{Cite pmid|34135895}}</ref> Transcriptomic Signature Differences Between SARS-CoV-2 and Influenza Virus Infected Patients #MMPMID34135895 Bibert S; Guex N; Lourenco J; Brahier T; Papadimitriou-Olivgeris M; Damonti L; Manuel O; Liechti R; Gotz L; Tschopp J; Quinodoz M; Vollenweider P; Pagani JL; Oddo M; Hugli O; Lamoth F; Erard V; Voide C; Delorenzi M; Rufer N; Candotti F; Rivolta C; Boillat-Blanco N; Bochud PY Front Immunol 2021[]; 12 (ä): 666163 PMID34135895show ga The reason why most individuals with COVID-19 have relatively limited symptoms while other develop respiratory distress with life-threatening complications remains unknown. Increasing evidence suggests that COVID-19 associated adverse outcomes mainly rely on dysregulated immunity. Here, we compared transcriptomic profiles of blood cells from 103 patients with different severity levels of COVID-19 with that of 27 healthy and 22 influenza-infected individuals. Data provided a complete overview of SARS-CoV-2-induced immune signature, including a dramatic defect in IFN responses, a reduction of toxicity-related molecules in NK cells, an increased degranulation of neutrophils, a dysregulation of T cells, a dramatic increase in B cell function and immunoglobulin production, as well as an important over-expression of genes involved in metabolism and cell cycle in patients infected with SARS-CoV-2 compared to those infected with influenza viruses. These features also differed according to COVID-19 severity. Overall and specific gene expression patterns across groups can be visualized on an interactive website (https://bix.unil.ch/covid/). Collectively, these transcriptomic host responses to SARS-CoV-2 infection are discussed in the context of current studies, thereby improving our understanding of COVID-19 pathogenesis and shaping the severity level of COVID-19. |COVID-19/*immunology[MESH] |Humans[MESH] |Influenza, Human/*immunology[MESH] |SARS-CoV-2/immunology[MESH]Transcriptomic Signature Differences Between SARS-CoV-2 and Influenza (epmc).pdf DeepDyve Pubget Overpricing