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10.1038/s41422-021-00523-8

http://scihub22266oqcxt.onion/10.1038/s41422-021-00523-8
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34135479!8208380!34135479
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suck abstract from ncbi


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pmid34135479      Cell+Res 2021 ; 31 (8): 836-846
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  • A cohort autopsy study defines COVID-19 systemic pathogenesis #MMPMID34135479
  • Yao XH; Luo T; Shi Y; He ZC; Tang R; Zhang PP; Cai J; Zhou XD; Jiang DP; Fei XC; Huang XQ; Zhao L; Zhang H; Wu HB; Ren Y; Liu ZH; Zhang HR; Chen C; Fu WJ; Li H; Xia XY; Chen R; Wang Y; Liu XD; Yin CL; Yan ZX; Wang J; Jing R; Li TS; Li WQ; Wang CF; Ding YQ; Mao Q; Zhang DY; Zhang SY; Ping YF; Bian XW
  • Cell Res 2021[Aug]; 31 (8): 836-846 PMID34135479show ga
  • Severe COVID-19 disease caused by SARS-CoV-2 is frequently accompanied by dysfunction of the lungs and extrapulmonary organs. However, the organotropism of SARS-CoV-2 and the port of virus entry for systemic dissemination remain largely unknown. We profiled 26 COVID-19 autopsy cases from four cohorts in Wuhan, China, and determined the systemic distribution of SARS-CoV-2. SARS-CoV-2 was detected in the lungs and multiple extrapulmonary organs of critically ill COVID-19 patients up to 67 days after symptom onset. Based on organotropism and pathological features of the patients, COVID-19 was divided into viral intrapulmonary and systemic subtypes. In patients with systemic viral distribution, SARS-CoV-2 was detected in monocytes, macrophages, and vascular endothelia at blood-air barrier, blood-testis barrier, and filtration barrier. Critically ill patients with long disease duration showed decreased pulmonary cell proliferation, reduced viral RNA, and marked fibrosis in the lungs. Permanent SARS-CoV-2 presence and tissue injuries in the lungs and extrapulmonary organs suggest direct viral invasion as a mechanism of pathogenicity in critically ill patients. SARS-CoV-2 may hijack monocytes, macrophages, and vascular endothelia at physiological barriers as the ports of entry for systemic dissemination. Our study thus delineates systemic pathological features of SARS-CoV-2 infection, which sheds light on the development of novel COVID-19 treatment.
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Autopsy[MESH]
  • |COVID-19/*pathology/virology[MESH]
  • |China[MESH]
  • |Cohort Studies[MESH]
  • |Critical Illness[MESH]
  • |Female[MESH]
  • |Fibrosis[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Kidney/pathology/virology[MESH]
  • |Leukocytes, Mononuclear/pathology/virology[MESH]
  • |Lung/pathology/*virology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |RNA, Viral/metabolism[MESH]
  • |SARS-CoV-2/genetics/*isolation & purification[MESH]
  • |Spleen/pathology/virology[MESH]


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