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10.1126/sciadv.abf8577 http://scihub22266oqcxt.onion/10.1126/sciadv.abf8577 34134991!8208716!34134991     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Adv 2021 ; 7 (25): ä Nephropedia Template TP {{tp|p=34134991|t=2021. Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severity |pdf=|usr=}}{{34134991}} gab.com Text Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severity JO: Sci Adv http://www.kidney.de/pget.php?&tw=1&pmid=34134991 #FOAvip Infection by highly pathogenic coronaviruses results in substantial apoptosis. However, the physiological relevance of apoptosis in the pathogenesis of coronavirus infections is unknown. Here, with a combination of in vitro, ex vivo, and in vivo models, we demonstrated that protein kinase R-like endoplasmic reticulum kinase (PERK) signaling mediated the proapoptotic signals in Middle East respiratory syndrome coronavirus (MERS-CoV) infection, which converged in the intrinsic apoptosis pathway. Inhibiting PERK signaling or intrinsic apoptosis both alleviated MERS pathogenesis in vivo. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and SARS-CoV induced apoptosis through distinct mechanisms but inhibition of intrinsic apoptosis similarly limited SARS-CoV-2- and SARS-CoV-induced apoptosis in vitro and markedly ameliorated the lung damage of SARS-CoV-2-inoculated human angiotensin-converting enzyme 2 (hACE2) mice. Collectively, our study provides the first evidence that virus-induced apoptosis is an important disease determinant of highly pathogenic coronaviruses and demonstrates that this process can be targeted to attenuate disease severity. Twit Text FOAVip Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severity ????Sci Adv http://www.kidney.de/pget.php?&tw=1&pmid=34134991 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34134991 #FOAvip English Wikipedia <ref>{{Cite pmid|34134991}}</ref> Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severity #MMPMID34134991 Chu H; Shuai H; Hou Y; Zhang X; Wen L; Huang X; Hu B; Yang D; Wang Y; Yoon C; Wong BH; Li C; Zhao X; Poon VK; Cai JP; Wong KK; Yeung ML; Zhou J; Au-Yeung RK; Yuan S; Jin DY; Kok KH; Perlman S; Chan JF; Yuen KY Sci Adv 2021[Jun]; 7 (25): ä PMID34134991show ga Infection by highly pathogenic coronaviruses results in substantial apoptosis. However, the physiological relevance of apoptosis in the pathogenesis of coronavirus infections is unknown. Here, with a combination of in vitro, ex vivo, and in vivo models, we demonstrated that protein kinase R-like endoplasmic reticulum kinase (PERK) signaling mediated the proapoptotic signals in Middle East respiratory syndrome coronavirus (MERS-CoV) infection, which converged in the intrinsic apoptosis pathway. Inhibiting PERK signaling or intrinsic apoptosis both alleviated MERS pathogenesis in vivo. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and SARS-CoV induced apoptosis through distinct mechanisms but inhibition of intrinsic apoptosis similarly limited SARS-CoV-2- and SARS-CoV-induced apoptosis in vitro and markedly ameliorated the lung damage of SARS-CoV-2-inoculated human angiotensin-converting enzyme 2 (hACE2) mice. Collectively, our study provides the first evidence that virus-induced apoptosis is an important disease determinant of highly pathogenic coronaviruses and demonstrates that this process can be targeted to attenuate disease severity. |*COVID-19 Drug Treatment[MESH] |Adenine/analogs & derivatives/pharmacology[MESH] |Angiotensin-Converting Enzyme 2/genetics[MESH] |Animals[MESH] |Antiviral Agents/*pharmacology[MESH] |Apoptosis/*drug effects/physiology[MESH] |COVID-19/etiology/pathology[MESH] |Cell Line[MESH] |Coronavirus Infections/*drug therapy/etiology/pathology[MESH] |Dipeptidyl Peptidase 4/genetics[MESH] |Epithelial Cells/virology[MESH] |Female[MESH] |Humans[MESH] |Indoles/pharmacology[MESH] |Lung/virology[MESH] |Male[MESH] |Mice, Transgenic[MESH]Targeting highly pathogenic coronavirus-induced apoptosis reduces vira(epmc).pdf DeepDyve Pubget Overpricing