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10.1016/j.celrep.2021.109237 http://scihub22266oqcxt.onion/10.1016/j.celrep.2021.109237 34133922!8220302!34133922     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34133922&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\34133922.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Rep 2021 ; 35 (11): 109237 Nephropedia Template TP {{tp|p=34133922|t=2021. Stress granules inhibit fatty acid oxidation by modulating mitochondrial permeability |pdf=|usr=}}{{34133922}} gab.com Text Stress granules inhibit fatty acid oxidation by modulating mitochondrial permeability JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=34133922 #FOAvip The formation of stress granules (SGs) is an essential aspect of the cellular response to many kinds of stress, but its adaptive role is far from clear. SG dysfunction is implicated in aging-onset neurodegenerative diseases, prompting interest in their physiological function. Here, we report that during starvation stress, SGs interact with mitochondria and regulate metabolic remodeling. We show that SG formation leads to a downregulation of fatty acid beta-oxidation (FAO) through the modulation of mitochondrial voltage-dependent anion channels (VDACs), which import fatty acids (FAs) into mitochondria. The subsequent decrease in FAO during long-term starvation reduces oxidative damage and rations FAs for longer use. Failure to form SGs, whether caused by the genetic deletion of SG components or an amyotrophic lateral sclerosis (ALS)-associated mutation, translates into an inability to downregulate FAO. Because metabolic dysfunction is a common pathological element of neurodegenerative diseases, including ALS, our findings provide a direction for studying the clinical relevance of SGs. Twit Text FOAVip Stress granules inhibit fatty acid oxidation by modulating mitochondrial permeability ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=34133922 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34133922 #FOAvip English Wikipedia <ref>{{Cite pmid|34133922}}</ref> Stress granules inhibit fatty acid oxidation by modulating mitochondrial permeability #MMPMID34133922 Amen T; Kaganovich D Cell Rep 2021[Jun]; 35 (11): 109237 PMID34133922show ga The formation of stress granules (SGs) is an essential aspect of the cellular response to many kinds of stress, but its adaptive role is far from clear. SG dysfunction is implicated in aging-onset neurodegenerative diseases, prompting interest in their physiological function. Here, we report that during starvation stress, SGs interact with mitochondria and regulate metabolic remodeling. We show that SG formation leads to a downregulation of fatty acid beta-oxidation (FAO) through the modulation of mitochondrial voltage-dependent anion channels (VDACs), which import fatty acids (FAs) into mitochondria. The subsequent decrease in FAO during long-term starvation reduces oxidative damage and rations FAs for longer use. Failure to form SGs, whether caused by the genetic deletion of SG components or an amyotrophic lateral sclerosis (ALS)-associated mutation, translates into an inability to downregulate FAO. Because metabolic dysfunction is a common pathological element of neurodegenerative diseases, including ALS, our findings provide a direction for studying the clinical relevance of SGs. |Amyotrophic Lateral Sclerosis/pathology[MESH] |Cell Line, Tumor[MESH] |Cell Lineage[MESH] |Fatty Acids/*metabolism[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Induced Pluripotent Stem Cells/metabolism[MESH] |Lipid Droplets/metabolism[MESH] |Mitochondria/*metabolism[MESH] |Neurons/pathology[MESH] |Oxidation-Reduction[MESH] |Permeability[MESH] |Starvation[MESH]Stress granules inhibit fatty acid oxidation by modulating mitochondri(epmc).pdf DeepDyve Pubget Overpricing