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10.1371/journal.pone.0249499 http://scihub22266oqcxt.onion/10.1371/journal.pone.0249499 34133415!8208542!34133415     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2021 ; 16 (6): e0249499 Nephropedia Template TP {{tp|p=34133415|t=2021. Human IgG and IgA responses to COVID-19 mRNA vaccines |pdf=|usr=}}{{34133415}} gab.com Text Human IgG and IgA responses to COVID-19 mRNA vaccines JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=34133415 #FOAvip SARS-CoV-2 spike antigen-specific IgG and IgA elicited by infection mediate viral neutralization and are likely an important component of natural immunity, however, limited information exists on vaccine induced responses. We measured COVID-19 mRNA vaccine induced IgG and IgA in serum serially, up to 145 days post vaccination in 4 subjects. Spike antigen-specific IgG levels rose exponentially and plateaued 21 days after the initial vaccine dose. After the second vaccine dose IgG levels increased further, reaching a maximum approximately 7-10 days later, and remained elevated (average of 58% peak levels) during the additional >100 day follow up period. COVID-19 mRNA vaccination elicited spike antigen-specific IgA with similar kinetics of induction and time to peak levels, but more rapid decline in serum levels following both the 1st and 2nd vaccine doses (<18% peak levels within 100 days of the 2nd shot). The data demonstrate COVID-19 mRNA vaccines effectively induce spike antigen specific IgG and IgA and highlight marked differences in their persistence in serum. Twit Text FOAVip Human IgG and IgA responses to COVID-19 mRNA vaccines ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=34133415 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34133415 #FOAvip English Wikipedia <ref>{{Cite pmid|34133415}}</ref> Human IgG and IgA responses to COVID-19 mRNA vaccines #MMPMID34133415 Wisnewski AV; Campillo Luna J; Redlich CA PLoS One 2021[]; 16 (6): e0249499 PMID34133415show ga SARS-CoV-2 spike antigen-specific IgG and IgA elicited by infection mediate viral neutralization and are likely an important component of natural immunity, however, limited information exists on vaccine induced responses. We measured COVID-19 mRNA vaccine induced IgG and IgA in serum serially, up to 145 days post vaccination in 4 subjects. Spike antigen-specific IgG levels rose exponentially and plateaued 21 days after the initial vaccine dose. After the second vaccine dose IgG levels increased further, reaching a maximum approximately 7-10 days later, and remained elevated (average of 58% peak levels) during the additional >100 day follow up period. COVID-19 mRNA vaccination elicited spike antigen-specific IgA with similar kinetics of induction and time to peak levels, but more rapid decline in serum levels following both the 1st and 2nd vaccine doses (<18% peak levels within 100 days of the 2nd shot). The data demonstrate COVID-19 mRNA vaccines effectively induce spike antigen specific IgG and IgA and highlight marked differences in their persistence in serum. |Antibodies, Neutralizing/blood/immunology[MESH] |Antibodies, Viral/blood/immunology[MESH] |COVID-19 Vaccines/genetics/*immunology[MESH] |COVID-19/blood/*immunology/virology[MESH] |Enzyme-Linked Immunosorbent Assay[MESH] |Female[MESH] |Humans[MESH] |Immunoglobulin A/blood/*immunology[MESH] |Immunoglobulin G/blood/*immunology[MESH] |Male[MESH] |Middle Aged[MESH] |RNA, Messenger/genetics/immunology[MESH] |SARS-CoV-2/genetics/*immunology/physiology[MESH] |Spike Glycoprotein, Coronavirus/genetics/immunology[MESH] |Vaccination[MESH]Human IgG and IgA responses to COVID-19 mRNA vaccines (epmc).pdf DeepDyve Pubget Overpricing