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10.1017/S0950268821001321

http://scihub22266oqcxt.onion/10.1017/S0950268821001321
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34130770!8267341!34130770
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suck abstract from ncbi


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pmid34130770      Epidemiol+Infect 2021 ; 149 (ä): e146
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  • Characteristics of systematic reviews evaluating treatments for COVID-19 registered in PROSPERO #MMPMID34130770
  • Zhang R; Gao Y; Xie D; Lian R; Tian J
  • Epidemiol Infect 2021[Jun]; 149 (ä): e146 PMID34130770show ga
  • Characteristics and research collaboration of registered systematic reviews (SRs) on treatment modalities for coronavirus disease-2019 (COVID-19) remain unclear. This study analysed research collaboration, interventions and outcome measures in registered SRs on COVID-19 treatments and pointed out the relevant problems. PROSPERO (international prospective register of systematic reviews) was searched for SRs on COVID-19 treatments as of 2 June 2020. Excel 2016 was used for descriptive analyses of the extracted data. VOSviewer 1.6.14 software was used to generate network maps for collaborations between countries and institutions. A total of 189 SRs were included, which were registered by 301 institutions from 39 countries. China (69, 36.50%) exhibited the highest output. Cooperation between countries was not close enough. As an institution, the Chengdu University of Traditional Chinese Medicine (7, 3.70%) had the highest output. There was close cooperation between institutions. Interventions included antiviral therapy (81, 42.86%), respiratory support (16, 8.47%), circulatory support (11, 5.82%), plasma therapy for convalescent patients (11, 5.82%), immunotherapy (9, 4.76%), TCM (traditional Chinese medicine) treatment (9, 4.76%), rehabilitation treatment (5, 2.65%), anti-inflammatory treatment (16, 8.47%) and other treatments (31, 16.40%). Concerning antiviral therapy (81, 42.86%), the most commonly used antiviral agents were chloroquine/hydroxychloroquine (26, 13.76%), followed by remdesivir (12, 6.35%), lobinavir/ritonavir (11, 5.82%), favipiravir (5, 2.65%), ribavirin (5, 2.65%), interferon (5, 2.65%), abiron (4, 2.12%) and abidor (4, 2.12%). The most frequently used primary and secondary outcomes were the mortality rate (92, 48.68%) and hospital stay length (48, 25.40%), respectively. The expression of the outcomes was not standardised. Many COVID-19 SRs on treatment modalities have been registered, with a low completion rate. Although there was some collaboration between countries and institutions in the currently registered SRs on treatment modalities for COVID-19 on PROSPERO, cooperation between countries should be further enhanced. More attention should be directed towards identifying deficiencies of outcome measures, and the standardisation of results should be maximised.
  • |Antiviral Agents/therapeutic use[MESH]
  • |COVID-19/*therapy[MESH]
  • |Databases, Factual/*statistics & numerical data[MESH]
  • |Humans[MESH]
  • |Internationality[MESH]
  • |Intersectoral Collaboration[MESH]
  • |SARS-CoV-2[MESH]
  • |Systematic Reviews as Topic[MESH]


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