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10.1016/j.mcpro.2021.100112

http://scihub22266oqcxt.onion/10.1016/j.mcpro.2021.100112
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suck abstract from ncbi


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pmid34129940      Mol+Cell+Proteomics 2021 ; 20 (ä): 100112
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  • MHC Phosphopeptides: Promising Targets for Immunotherapy of Cancer and Other Chronic Diseases #MMPMID34129940
  • Mahoney KE; Shabanowitz J; Hunt DF
  • Mol Cell Proteomics 2021[]; 20 (ä): 100112 PMID34129940show ga
  • Major histocompatibility complex-associated peptides have been considered as potential immunotherapeutic targets for many years. MHC class I phosphopeptides result from dysregulated cell signaling pathways that are common across cancers and both viral and bacterial infections. These antigens are recognized by central memory T cells from healthy donors, indicating that they are considered antigenic by the immune system and that they are presented across different individuals and diseases. Based on these responses and the similar dysregulation, phosphorylated antigens are promising candidates for prevention or treatment of different cancers as well as a number of other chronic diseases.
  • |Histocompatibility Antigens Class I/*metabolism/pharmacology[MESH]
  • |Humans[MESH]
  • |Immunotherapy/*methods[MESH]
  • |Memory T Cells/immunology/metabolism[MESH]
  • |Neurodegenerative Diseases/*metabolism[MESH]
  • |Phosphopeptides/*metabolism/pharmacology[MESH]
  • |Protein Phosphatase 2/antagonists & inhibitors/metabolism[MESH]


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