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10.1017/S0007114521002099

http://scihub22266oqcxt.onion/10.1017/S0007114521002099
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34128459!8438509!34128459
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suck abstract from ncbi


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pmid34128459      Br+J+Nutr 2022 ; 127 (8): 1172-1179
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  • Antiviral and immunological activity of zinc and possible role in COVID-19 #MMPMID34128459
  • Marreiro DDN; Cruz KJC; Oliveira ARS; Morais JBS; Freitas BJESA; Melo SRS; Dos Santos LR; Cardoso BEP; Dias TMDS
  • Br J Nutr 2022[Apr]; 127 (8): 1172-1179 PMID34128459show ga
  • Zn deficiency compromises its biological functions, its effect on the immune system and its antiviral activity, increasing vulnerability to infectious diseases. This narrative review aims at presenting and discussing functional aspects and possible mechanisms involved in the potential role of Zn in the immune response and antiviral activity for coronavirus infectious disease-19 (COVID-19) prevention and control. The searches were conducted in PubMed and Science Direct databases, using clinical trials, experimental studies in animals and humans, case-control studies, case series, letters to the editor, and review articles published in English, without restrictions on year of publication. Search approach was based on using the terms: 'zinc', 'COVID-19', 'antiviral agents', 'immunologic factors' and 'respiratory tract infections'. Literature shows the importance of Zn as an essential mineral immunomodulator with relevant antiviral activity in the body. Thus, although there is still a scarcity of studies evaluating Zn supplementation in patients with COVID-19, the results on the topic show the necessity of controlling Zn mineral deficiency, as well as maintaining its homoeostasis in the body in order to strengthen the immune system and improve the prevention of highly complex viral infections, such as that of the COVID-19.
  • |*COVID-19 Drug Treatment[MESH]
  • |*Communicable Diseases/drug therapy[MESH]
  • |*Virus Diseases[MESH]
  • |Antiviral Agents/pharmacology/therapeutic use[MESH]
  • |Humans[MESH]


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