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10.1177/03913988211023782 http://scihub22266oqcxt.onion/10.1177/03913988211023782 34128416!ä!34128416 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Artif+Organs 2021 ; 44 (10): 664-674 Nephropedia Template TP {{tp|p=34128416|t=2021. Continuous hemadsorption with cytokine adsorber for severe COVID-19: A case series of 15 patients |pdf=|usr=}}{{34128416}} gab.com Text Continuous hemadsorption with cytokine adsorber for severe COVID-19: A case series of 15 patients JO: Int J Artif Organs http://www.kidney.de/pget.php?&tw=1&pmid=34128416 #FOAvip BACKGROUND: Hyperinflammation and cytokine release has been associated with severe Covid-19. Hemadsorption cartridges may have a potential role in treatment of cytokine storm associated with the development of severe Covid-19. METHODS: We retrospectively examined the case records of patients with severe Covid-19 receiving adjunctive hemadsorption (HA) in our ICU. We analyzed inflammatory biomarkers pre- and post- HA. RESULTS: Fifteen patients received HA during the study period. All were intubated, ventilated and required renal replacement therapy. 11/15 were supported on ECMO. Mean ferritin 2652 (+/-3286) ng/ml, mean CRP 154 (+/-92) mg/ml, median D-dimer 3071 (+/-2689) ng/ml, mean troponin 236 (+/-461) ng/L. We found significant difference in pre-and post- treatment ferritin 3622 ng/ml versus 1682 ng/ml (p = 0.022), CRP 222 mg/ml versus 103 mg/ml (p = 0.008, 95% CI 22.4-126.5), lactate 2 mmol/L versus 1.3 mmol/L (p = 0.017), and procalcitonin 15.3 ng/ml versus 4.2 ng/ml (p = 0.023). No significant difference in pre- and post- treatment IL-6 14 pg/ml versus 43 pg/ml (p = 0.32), IL-10 3.4 pg/ml versus 2.6 pg/ml (p = 0.31), IL1 beta 0.37 pg/ml versus 0.77 pg/ml (p = 0.75), TNF alpha 12.77 pg/ml versus 12.49 pg/ml (p = 0.75), VIS 10.04 versus 6.01 (p = 0.31, 95% CI 5.98-17.16) was seen. CONCLUSIONS: The use of HA as adjunctive treatment in a critically unwell group of COVID-19 patients lead to a reduction in ferritin, CRP, procalcitonin and lactate with no significant change in other parameters. The use of HA in the treatment of severe COVID-19 requires further larger randomized studies. Twit Text FOAVip Continuous hemadsorption with cytokine adsorber for severe COVID-19: A case series of 15 patients ????Int J Artif Organs http://www.kidney.de/pget.php?&tw=1&pmid=34128416 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34128416 #FOAvip English Wikipedia <ref>{{Cite pmid|34128416}}</ref> Continuous hemadsorption with cytokine adsorber for severe COVID-19: A case series of 15 patients #MMPMID34128416 Paisey C; Patvardhan C; Mackay M; Vuylsteke A; Bhagra SK Int J Artif Organs 2021[Oct]; 44 (10): 664-674 PMID34128416show ga BACKGROUND: Hyperinflammation and cytokine release has been associated with severe Covid-19. Hemadsorption cartridges may have a potential role in treatment of cytokine storm associated with the development of severe Covid-19. METHODS: We retrospectively examined the case records of patients with severe Covid-19 receiving adjunctive hemadsorption (HA) in our ICU. We analyzed inflammatory biomarkers pre- and post- HA. RESULTS: Fifteen patients received HA during the study period. All were intubated, ventilated and required renal replacement therapy. 11/15 were supported on ECMO. Mean ferritin 2652 (+/-3286) ng/ml, mean CRP 154 (+/-92) mg/ml, median D-dimer 3071 (+/-2689) ng/ml, mean troponin 236 (+/-461) ng/L. We found significant difference in pre-and post- treatment ferritin 3622 ng/ml versus 1682 ng/ml (p = 0.022), CRP 222 mg/ml versus 103 mg/ml (p = 0.008, 95% CI 22.4-126.5), lactate 2 mmol/L versus 1.3 mmol/L (p = 0.017), and procalcitonin 15.3 ng/ml versus 4.2 ng/ml (p = 0.023). No significant difference in pre- and post- treatment IL-6 14 pg/ml versus 43 pg/ml (p = 0.32), IL-10 3.4 pg/ml versus 2.6 pg/ml (p = 0.31), IL1 beta 0.37 pg/ml versus 0.77 pg/ml (p = 0.75), TNF alpha 12.77 pg/ml versus 12.49 pg/ml (p = 0.75), VIS 10.04 versus 6.01 (p = 0.31, 95% CI 5.98-17.16) was seen. CONCLUSIONS: The use of HA as adjunctive treatment in a critically unwell group of COVID-19 patients lead to a reduction in ferritin, CRP, procalcitonin and lactate with no significant change in other parameters. The use of HA in the treatment of severe COVID-19 requires further larger randomized studies. |*COVID-19[MESH] |Cytokines[MESH] |Hemadsorption[MESH] |Humans[MESH] |Retrospective Studies[MESH]Continuous hemadsorption with cytokine adsorber for severe COVID-19: A(epmc).pdf DeepDyve Pubget Overpricing