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10.21203/rs.3.rs-539712/v1 http://scihub22266oqcxt.onion/10.21203/rs.3.rs-539712/v1 34127963!8202429!34127963     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Res+Sq 2021 ; ä (ä): ä Nephropedia Template TP {{tp|p=34127963|t=2021. Plasma Proteomics of COVID-19 Associated Cardiovascular Complications: Implications for Pathophysiology and Therapeutics |pdf=|usr=}}{{34127963}} gab.com Text Plasma Proteomics of COVID-19 Associated Cardiovascular Complications: Implications for Pathophysiology and Therapeutics JO: Res Sq http://www.kidney.de/pget.php?&tw=1&pmid=34127963 #FOAvip Cardiovascular complications are common in COVID-19 and strongly associated with disease severity and mortality. However, the mechanisms driving cardiac injury and failure in COVID-19 are largely unknown. We performed plasma proteomics on 80 COVID-19 patients and controls, grouped according to disease severity and cardiac involvement. Findings were validated in 305 independent COVID-19 patients and investigated in an animal model. Here we show that senescence-associated secretory proteins, markers of biological aging, strongly associate with disease severity and cardiac involvement even in age-matched cohorts. FSTL3, an indicator of Activin/TGFbeta signaling, was the most significantly upregulated protein associated with the heart failure biomarker, NTproBNP (beta = 0.4;p (adj) =4.6x10 (- 7) ), while ADAMTS13, a vWF-cleaving protease whose loss-of-function causes microvascular thrombosis, was the most downregulated protein associated with myocardial injury (beta=-0.4;p (adj) =8x10 (- 7) ). Mendelian randomization supported a causal role for ADAMTS13 in myocardial injury. These data provide important new insights into the pathophysiology of COVID-19 cardiovascular complications with therapeutic implications. Twit Text FOAVip Plasma Proteomics of COVID-19 Associated Cardiovascular Complications: Implications for Pathophysiology and Therapeutics ????Res Sq http://www.kidney.de/pget.php?&tw=1&pmid=34127963 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34127963 #FOAvip English Wikipedia <ref>{{Cite pmid|34127963}}</ref> Plasma Proteomics of COVID-19 Associated Cardiovascular Complications: Implications for Pathophysiology and Therapeutics #MMPMID34127963 Roh J; Kitchen R; Guseh JS; McNeill J; Aid M; Martinot A; Yu A; Platt C; Rhee J; Weber B; Trager L; Hastings M; Ducat S; Xia P; Castro C; Atlason B; Churchill T; Di Carli M; Ellinor P; Barouch D; Ho J; Rosenzweig A Res Sq 2021[Jun]; ä (ä): ä PMID34127963show ga Cardiovascular complications are common in COVID-19 and strongly associated with disease severity and mortality. However, the mechanisms driving cardiac injury and failure in COVID-19 are largely unknown. We performed plasma proteomics on 80 COVID-19 patients and controls, grouped according to disease severity and cardiac involvement. Findings were validated in 305 independent COVID-19 patients and investigated in an animal model. Here we show that senescence-associated secretory proteins, markers of biological aging, strongly associate with disease severity and cardiac involvement even in age-matched cohorts. FSTL3, an indicator of Activin/TGFbeta signaling, was the most significantly upregulated protein associated with the heart failure biomarker, NTproBNP (beta = 0.4;p (adj) =4.6x10 (- 7) ), while ADAMTS13, a vWF-cleaving protease whose loss-of-function causes microvascular thrombosis, was the most downregulated protein associated with myocardial injury (beta=-0.4;p (adj) =8x10 (- 7) ). Mendelian randomization supported a causal role for ADAMTS13 in myocardial injury. These data provide important new insights into the pathophysiology of COVID-19 cardiovascular complications with therapeutic implications. äPlasma Proteomics of COVID-19 Associated Cardiovascular Complications:(epmc).pdf DeepDyve Pubget Overpricing