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10.1016/j.isci.2021.102711 http://scihub22266oqcxt.onion/10.1016/j.isci.2021.102711 34127958!8189740!34127958     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       iScience 2021 ; 24 (7): 102711 Nephropedia Template TP {{tp|p=34127958|t=2021. CD177, a specific marker of neutrophil activation, is associated with coronavirus disease 2019 severity and death |pdf=|usr=}}{{34127958}} gab.com Text CD177, a specific marker of neutrophil activation, is associated with coronavirus disease 2019 severity and death JO: iScience http://www.kidney.de/pget.php?&tw=1&pmid=34127958 #FOAvip The identification of patients with coronavirus disease 2019 and high risk of severe disease is a challenge in routine care. We performed cell phenotypic, serum, and RNA sequencing gene expression analyses in severe hospitalized patients (n = 61). Relative to healthy donors, results showed abnormalities of 27 cell populations and an elevation of 42 cytokines, neutrophil chemo-attractants, and inflammatory components in patients. Supervised and unsupervised analyses revealed a high abundance of CD177, a specific neutrophil activation marker, contributing to the clustering of severe patients. Gene abundance correlated with high serum levels of CD177 in severe patients. Higher levels were confirmed in a second cohort and in intensive care unit (ICU) than non-ICU patients (P < 0.001). Longitudinal measurements discriminated between patients with the worst prognosis, leading to death, and those who recovered (P = 0.01). These results highlight neutrophil activation as a hallmark of severe disease and CD177 assessment as a reliable prognostic marker for routine care. Twit Text FOAVip CD177, a specific marker of neutrophil activation, is associated with coronavirus disease 2019 severity and death ????iScience http://www.kidney.de/pget.php?&tw=1&pmid=34127958 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34127958 #FOAvip English Wikipedia <ref>{{Cite pmid|34127958}}</ref> CD177, a specific marker of neutrophil activation, is associated with coronavirus disease 2019 severity and death #MMPMID34127958 Levy Y; Wiedemann A; Hejblum BP; Durand M; Lefebvre C; Surenaud M; Lacabaratz C; Perreau M; Foucat E; Dechenaud M; Tisserand P; Blengio F; Hivert B; Gauthier M; Cervantes-Gonzalez M; Bachelet D; Laouenan C; Bouadma L; Timsit JF; Yazdanpanah Y; Pantaleo G; Hocini H; Thiebaut R iScience 2021[Jul]; 24 (7): 102711 PMID34127958show ga The identification of patients with coronavirus disease 2019 and high risk of severe disease is a challenge in routine care. We performed cell phenotypic, serum, and RNA sequencing gene expression analyses in severe hospitalized patients (n = 61). Relative to healthy donors, results showed abnormalities of 27 cell populations and an elevation of 42 cytokines, neutrophil chemo-attractants, and inflammatory components in patients. Supervised and unsupervised analyses revealed a high abundance of CD177, a specific neutrophil activation marker, contributing to the clustering of severe patients. Gene abundance correlated with high serum levels of CD177 in severe patients. Higher levels were confirmed in a second cohort and in intensive care unit (ICU) than non-ICU patients (P < 0.001). Longitudinal measurements discriminated between patients with the worst prognosis, leading to death, and those who recovered (P = 0.01). These results highlight neutrophil activation as a hallmark of severe disease and CD177 assessment as a reliable prognostic marker for routine care. äCD177, a specific marker of neutrophil activation, is associated with (epmc).pdf DeepDyve Pubget Overpricing