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Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Curr+Drug+Res+Rev 2021 ; 13 (3): 184-202 Nephropedia Template TP
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Potential Drugs for the Treatment of COVID-19: Synthesis, Brief History and Application #MMPMID34126913
Uddin E; Islam R; Ashrafuzzaman; Bitu NA; Hossain MS; Islam AN; Asraf A; Hossen F; Mohapatra RK; Kudrat-E-Zahan M
Curr Drug Res Rev 2021[]; 13 (3): 184-202 PMID34126913show ga
Coronaviruses (CoVs) belong to the Betacoronavirus group, an unusually large RNA genome characterized by club-like spikes that project from their surface. An outbreak of a novel coronavirus 2019 (nCOVID-19) already showed a unique replication strategy and infection that has posed significant threat to international health and the economy around the globe. Scientists around the world are investigating few previously used clinical drugs for the treatment of COVID-19. This review provides synthesis and mode of action of recently investigated drugs like Chloroquine, Hydroxychloroquine, Ivermectin, Selamectin, Remdesivir, Baricitinib, Darunavir, Favipiravir, Lopinavir/ ritonavir and Mefloquine hydrochloride that constitute an option for COVID-19 treatment.