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10.1016/j.ejphar.2021.174248 http://scihub22266oqcxt.onion/10.1016/j.ejphar.2021.174248 34126092!8195694!34126092     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34126092&cmd=llinks): Failed to open stream: HTTP request failed! 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Interferon therapy in patients with SARS, MERS, and COVID-19: A systematic review and meta-analysis of clinical studies |pdf=|usr=}}{{34126092}} gab.com Text Interferon therapy in patients with SARS, MERS, and COVID-19: A systematic review and meta-analysis of clinical studies JO: Eur J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=34126092 #FOAvip Concern regarding coronavirus (CoV) outbreaks has stayed relevant to global health in the last decades. Emerging COVID-19 infection, caused by the novel SARS-CoV2, is now a pandemic, bringing a substantial burden to human health. Interferon (IFN), combined with other antivirals and various treatments, has been used to treat and prevent MERS-CoV, SARS-CoV, and SARS-CoV2 infections. We aimed to assess the clinical efficacy of IFN-based treatments and combinational therapy with antivirals, corticosteroids, traditional medicine, and other treatments. Major healthcare databases and grey literature were investigated. A three-stage screening was utilized, and included studies were checked against the protocol eligibility criteria. Risk of bias assessment and data extraction were performed, followed by narrative data synthesis. Fifty-five distinct studies of SARS-CoV2, MERS-CoV, and SARS-CoV were spotted. Our narrative synthesis showed a possible benefit in the use of IFN. A good quality cohort showed lower CRP levels in Arbidol (ARB) + IFN group vs. IFN only group. Another study reported a significantly shorter chest X-ray (CXR) resolution in IFN-Alfacon-1 + corticosteroid group compared with the corticosteroid only group in SARS-CoV patients. In a COVID-19 trial, total adverse drug events (ADEs) were much lower in the Favipiravir (FPV) + IFN-alpha group compared with the LPV/RTV arm (P = 0.001). Also, nausea in patients receiving FPV + IFN-alpha regimen was significantly lower (P = 0.03). Quantitative analysis of mortality did not show a conclusive effect for IFN/RBV treatment in six moderately heterogeneous MERS-CoV studies (log OR = -0.05, 95% CI: (-0.71,0.62), I(2) = 44.71%). A meta-analysis of three COVID-19 studies did not show a conclusive nor meaningful relation between receiving IFN and COVID-19 severity (log OR = -0.44, 95% CI: (-1.13,0.25), I(2) = 31.42%). A lack of high-quality cohorts and controlled trials was observed. Evidence suggests the potential efficacy of several combination IFN therapies such as lower ADEs, quicker resolution of CXR, or a decrease in inflammatory cytokines; Still, these options must possibly be further explored before being recommended in public guidelines. For all major CoVs, our results may indicate a lack of a definitive effect of IFN treatment on mortality. We recommend such therapeutics be administered with extreme caution until further investigation uncovers high-quality evidence in favor of IFN or combination therapy with IFN. Twit Text FOAVip Interferon therapy in patients with SARS, MERS, and COVID-19: A systematic review and meta-analysis of clinical studies ????Eur J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=34126092 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34126092 #FOAvip English Wikipedia <ref>{{Cite pmid|34126092}}</ref> Interferon therapy in patients with SARS, MERS, and COVID-19: A systematic review and meta-analysis of clinical studies #MMPMID34126092 Saleki K; Yaribash S; Banazadeh M; Hajihosseinlou E; Gouravani M; Saghazadeh A; Rezaei N Eur J Pharmacol 2021[Sep]; 906 (ä): 174248 PMID34126092show ga Concern regarding coronavirus (CoV) outbreaks has stayed relevant to global health in the last decades. Emerging COVID-19 infection, caused by the novel SARS-CoV2, is now a pandemic, bringing a substantial burden to human health. Interferon (IFN), combined with other antivirals and various treatments, has been used to treat and prevent MERS-CoV, SARS-CoV, and SARS-CoV2 infections. We aimed to assess the clinical efficacy of IFN-based treatments and combinational therapy with antivirals, corticosteroids, traditional medicine, and other treatments. Major healthcare databases and grey literature were investigated. A three-stage screening was utilized, and included studies were checked against the protocol eligibility criteria. Risk of bias assessment and data extraction were performed, followed by narrative data synthesis. Fifty-five distinct studies of SARS-CoV2, MERS-CoV, and SARS-CoV were spotted. Our narrative synthesis showed a possible benefit in the use of IFN. A good quality cohort showed lower CRP levels in Arbidol (ARB) + IFN group vs. IFN only group. Another study reported a significantly shorter chest X-ray (CXR) resolution in IFN-Alfacon-1 + corticosteroid group compared with the corticosteroid only group in SARS-CoV patients. In a COVID-19 trial, total adverse drug events (ADEs) were much lower in the Favipiravir (FPV) + IFN-alpha group compared with the LPV/RTV arm (P = 0.001). Also, nausea in patients receiving FPV + IFN-alpha regimen was significantly lower (P = 0.03). Quantitative analysis of mortality did not show a conclusive effect for IFN/RBV treatment in six moderately heterogeneous MERS-CoV studies (log OR = -0.05, 95% CI: (-0.71,0.62), I(2) = 44.71%). A meta-analysis of three COVID-19 studies did not show a conclusive nor meaningful relation between receiving IFN and COVID-19 severity (log OR = -0.44, 95% CI: (-1.13,0.25), I(2) = 31.42%). A lack of high-quality cohorts and controlled trials was observed. Evidence suggests the potential efficacy of several combination IFN therapies such as lower ADEs, quicker resolution of CXR, or a decrease in inflammatory cytokines; Still, these options must possibly be further explored before being recommended in public guidelines. For all major CoVs, our results may indicate a lack of a definitive effect of IFN treatment on mortality. We recommend such therapeutics be administered with extreme caution until further investigation uncovers high-quality evidence in favor of IFN or combination therapy with IFN. |*COVID-19 Drug Treatment[MESH] |Antiviral Agents/adverse effects/*therapeutic use[MESH] |COVID-19/diagnostic imaging/mortality[MESH] |Coronavirus Infections/diagnostic imaging/*drug therapy/mortality[MESH] |Humans[MESH] |Interferons/adverse effects/*therapeutic use[MESH]Interferon therapy in patients with SARS, MERS, and COVID-19: A system(epmc).pdf DeepDyve Pubget Overpricing