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10.1021/acs.joc.1c00761 http://scihub22266oqcxt.onion/10.1021/acs.joc.1c00761 34126010!ä!34126010 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Org+Chem 2021 ; 86 (13): 8843-8850 Nephropedia Template TP {{tp|p=34126010|t=2021. Chemical Synthesis of the Antiviral Nucleotide Analogue ddhCTP |pdf=|usr=}}{{34126010}} gab.com Text Chemical Synthesis of the Antiviral Nucleotide Analogue ddhCTP JO: J Org Chem http://www.kidney.de/pget.php?&tw=1&pmid=34126010 #FOAvip 3'-Deoxy-3',4'-didehydro-cytidine triphosphate (ddhCTP) is a novel antiviral molecule produced by the enzyme viperin as part of the innate immune response. ddhCTP has been shown to act as an obligate chain terminator of flavivirus and SARS-CoV-2 RNA-dependent RNA polymerases; however, further biophysical studies have been precluded by limited access to this promising antiviral. Herein, we report a robust and scalable synthesis of ddhCTP as well as the mono- and diphosphates ddhCMP and ddhCDP, respectively. Identification of a 2'-silyl ether protection strategy enabled selective synthesis and facile purification of the 5'-triphosphate, culminating in the preparation of ddhCTP on a gram scale. Twit Text FOAVip Chemical Synthesis of the Antiviral Nucleotide Analogue ddhCTP ????J Org Chem http://www.kidney.de/pget.php?&tw=1&pmid=34126010 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34126010 #FOAvip English Wikipedia <ref>{{Cite pmid|34126010}}</ref> Chemical Synthesis of the Antiviral Nucleotide Analogue ddhCTP #MMPMID34126010 Wood JM; Evans GB; Grove TL; Almo SC; Cameron SA; Furneaux RH; Harris LD J Org Chem 2021[Jul]; 86 (13): 8843-8850 PMID34126010show ga 3'-Deoxy-3',4'-didehydro-cytidine triphosphate (ddhCTP) is a novel antiviral molecule produced by the enzyme viperin as part of the innate immune response. ddhCTP has been shown to act as an obligate chain terminator of flavivirus and SARS-CoV-2 RNA-dependent RNA polymerases; however, further biophysical studies have been precluded by limited access to this promising antiviral. Herein, we report a robust and scalable synthesis of ddhCTP as well as the mono- and diphosphates ddhCMP and ddhCDP, respectively. Identification of a 2'-silyl ether protection strategy enabled selective synthesis and facile purification of the 5'-triphosphate, culminating in the preparation of ddhCTP on a gram scale. |*Antiviral Agents[MESH] |*COVID-19[MESH] |Cytidine Triphosphate[MESH] |Humans[MESH] |Proteins[MESH] |RNA, Viral[MESH]Chemical Synthesis of the Antiviral Nucleotide Analogue ddhCTP (epmc).pdf DeepDyve Pubget Overpricing