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10.1111/vox.13162 http://scihub22266oqcxt.onion/10.1111/vox.13162 34125976!8447161!34125976     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Vox+Sang 2022 ; 117 (2): 185-192 Nephropedia Template TP {{tp|p=34125976|t=2022. Qualifying coronavirus disease 2019 convalescent plasma donors in Israel |pdf=|usr=}}{{34125976}} gab.com Text Qualifying coronavirus disease 2019 convalescent plasma donors in Israel JO: Vox Sang http://www.kidney.de/pget.php?&tw=1&pmid=34125976 #FOAvip BACKGROUND AND OBJECTIVES: Passive immunization using investigational COVID-19 convalescent plasma (CCP) is a promising therapeutic strategy and could improve outcome if transfused early and contain high levels of anti-SARS-CoV-2 antibodies. We report the management of a national CCP collection and distribution program in Israel. MATERIALS AND METHODS: From 1 April 2020 to 15 January 2021, 4020 volunteer donors donated 5221 CCP units and 837 (20.8%) donors donated more than once. Anti-nucleocapsid IgG antibodies were determined using chemiluminescent immunoassay method (Abbott). A statistical model based on repeated IgG tests in sequential donations was created to predict the time of antibody decline below sample/cut-off (S/CO) level of 4.0. RESULTS: Ninety-six percent of CCP donors suffered a mild disease or were asymptomatic. Older donors had higher antibody levels. Higher antibody levels (S/CO >/=4) were detected in 35.2% of the donors. Low positive (S/CO >/=1.4-3.99) were found in 37%, and 27.8% had undetectable antibodies (S/CO </=1.4). The model predicted decrease antibody thresholds of 0.55%/day since the first CCP donation, providing guidance for the effective timing of future collections from donors with high antibody levels. CONCLUSIONS: An efficient CCP collection and distribution program was achieved, based on performing initial and repeated plasma collections, preferably from donors with higher antibody levels, and only antibody-rich units were supplied for therapeutic use. The inventory met the quantity and quality standards of the authorities, enabled to respond to the growing demand of the medical system and provide a product that may contribute to improve prognosis in patients with COVID-19. Twit Text FOAVip Qualifying coronavirus disease 2019 convalescent plasma donors in Israel ????Vox Sang http://www.kidney.de/pget.php?&tw=1&pmid=34125976 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34125976 #FOAvip English Wikipedia <ref>{{Cite pmid|34125976}}</ref> Qualifying coronavirus disease 2019 convalescent plasma donors in Israel #MMPMID34125976 Izak M; Gendelman V; Bransburg-Zabary S; Stoyanov E; Gat R; Cohen D; Chen J; Maor Y; Benov A; Lev B; Zimhony O; Shinar E Vox Sang 2022[Feb]; 117 (2): 185-192 PMID34125976show ga BACKGROUND AND OBJECTIVES: Passive immunization using investigational COVID-19 convalescent plasma (CCP) is a promising therapeutic strategy and could improve outcome if transfused early and contain high levels of anti-SARS-CoV-2 antibodies. We report the management of a national CCP collection and distribution program in Israel. MATERIALS AND METHODS: From 1 April 2020 to 15 January 2021, 4020 volunteer donors donated 5221 CCP units and 837 (20.8%) donors donated more than once. Anti-nucleocapsid IgG antibodies were determined using chemiluminescent immunoassay method (Abbott). A statistical model based on repeated IgG tests in sequential donations was created to predict the time of antibody decline below sample/cut-off (S/CO) level of 4.0. RESULTS: Ninety-six percent of CCP donors suffered a mild disease or were asymptomatic. Older donors had higher antibody levels. Higher antibody levels (S/CO >/=4) were detected in 35.2% of the donors. Low positive (S/CO >/=1.4-3.99) were found in 37%, and 27.8% had undetectable antibodies (S/CO |*COVID-19/therapy[MESH] |Blood Donors[MESH] |COVID-19 Serotherapy[MESH] |Humans[MESH] |Immunization, Passive[MESH] |Israel[MESH]Qualifying coronavirus disease 2019 convalescent plasma donors in Isra(epmc).pdf DeepDyve Pubget Overpricing