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Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 EJHaem 2021 ; 2 (2): 175-187 Nephropedia Template TP
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Blood group type A secretors are associated with a higher risk of COVID-19 cardiovascular disease complications #MMPMID34124710
Mankelow TJ; Singleton BK; Moura PL; Stevens-Hernandez CJ; Cogan NM; Gyorffy G; Kupzig S; Nichols L; Asby C; Pooley J; Ruffino G; Hosseini F; Moghaddas F; Attwood M; Noel A; Cooper A; Arnold DT; Hamilton F; Hyams C; Finn A; Toye AM; Anstee DJ
EJHaem 2021[May]; 2 (2): 175-187 PMID34124710show ga
The SARS-CoV-2 virus causes COVID-19, an infection capable of causing severe disease and death but which can also be asymptomatic or oligosymptomatic. We investigated whether ABO blood group or secretor status was associated with COVID-19 severity. We investigated secretor status because expression of ABO glycans on secreted proteins and non-erythroid cells are controlled by a fucosyltransferase (FUT2), and inactivating FUT2 mutations result in a non-secretor phenotype which protects against some viral infections. Data combined from healthcare records and our own laboratory tests (n = 275) of hospitalized SARS-CoV-2 polymerase chain reaction positive patients confirmed higher than expected numbers of blood group A individuals compared to O (RR = 1.24, CI 95% [1.05, 1.47], p = 0.0111). There was also a significant association between group A and COVID-19-related cardiovascular complications (RR = 2.56, CI 95% [1.43, 4.55], p = 0.0011) which is independent of gender. Molecular analysis revealed that group A non-secretors are significantly less likely to be hospitalized than secretors. Testing of convalescent plasma donors, among whom the majority displayed COVID-19 symptoms and only a small minority required hospitalization, group A non-secretors were slightly over-represented. Our findings showed that group A non-secretors are not resistant to infection by SARS-CoV-2, but are more likely to experience a less severe form of associated disease.