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10.21769/BioProtoc.3999

http://scihub22266oqcxt.onion/10.21769/BioProtoc.3999
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34124300!8160537!34124300
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suck abstract from ncbi


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pmid34124300      Bio+Protoc 2021 ; 11 (8): e3999
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  • Computational Analysis and Phylogenetic Clustering of SARS-CoV-2 Genomes #MMPMID34124300
  • Jolly B; Scaria V
  • Bio Protoc 2021[Apr]; 11 (8): e3999 PMID34124300show ga
  • COVID-19, the disease caused by the novel SARS-CoV-2 coronavirus, originated as an isolated outbreak in the Hubei province of China but soon created a global pandemic and is now a major threat to healthcare systems worldwide. Following the rapid human-to-human transmission of the infection, institutes around the world have made efforts to generate genome sequence data for the virus. With thousands of genome sequences for SARS-CoV-2 now available in the public domain, it is possible to analyze the sequences and gain a deeper understanding of the disease, its origin, and its epidemiology. Phylogenetic analysis is a potentially powerful tool for tracking the transmission pattern of the virus with a view to aiding identification of potential interventions. Toward this goal, we have created a comprehensive protocol for the analysis and phylogenetic clustering of SARS-CoV-2 genomes using Nextstrain, a powerful open-source tool for the real-time interactive visualization of genome sequencing data. Approaches to focus the phylogenetic clustering analysis on a particular region of interest are detailed in this protocol.
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