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10.3389/fcvm.2021.681948

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pmid34124207      Front+Cardiovasc+Med 2021 ; 8 (ä): 681948
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  • The Notch Pathway: A Link Between COVID-19 Pathophysiology and Its Cardiovascular Complications #MMPMID34124207
  • Breikaa RM; Lilly B
  • Front Cardiovasc Med 2021[]; 8 (ä): 681948 PMID34124207show ga
  • COVID-19 is associated with a large number of cardiovascular sequelae, including dysrhythmias, myocardial injury, myocarditis and thrombosis. The Notch pathway is one likely culprit leading to these complications due to its direct role in viral entry, inflammation and coagulation processes, all shown to be key parts of COVID-19 pathogenesis. This review highlights links between the pathophysiology of SARS-CoV2 and the Notch signaling pathway that serve as primary drivers of the cardiovascular complications seen in COVID-19 patients.
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