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10.1002/sim.9094 http://scihub22266oqcxt.onion/10.1002/sim.9094 34120357!8441767!34120357     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Stat+Med 2021 ; 40 (22): 4890-4913 Nephropedia Template TP {{tp|p=34120357|t=2021. Exact sequential test for clinical trials and post-market drug and vaccine safety surveillance with Poisson and binary data |pdf=|usr=}}{{34120357}} gab.com Text Exact sequential test for clinical trials and post-market drug and vaccine safety surveillance with Poisson and binary data JO: Stat Med http://www.kidney.de/pget.php?&tw=1&pmid=34120357 #FOAvip In sequential analysis, hypothesis testing is performed repeatedly in a prospective manner as data accrue over time to quickly arrive at an accurate conclusion or decision. In this tutorial paper, detailed explanations are given for both designing and operating sequential testing. We describe the calculation of exact thresholds for stopping or signaling, statistical power, expected time to signal, and expected sample sizes for sequential analysis with Poisson and binary type data. The calculations are run using the package Sequential, constructed in R language. Real data examples are inspired on clinical trials practice, such as the current efforts to develop treatments to face the COVID-19 pandemic, and the comparison of treatments of osteoporosis. In addition, we mimic the monitoring of adverse events following influenza vaccination and Pediarix vaccination. Twit Text FOAVip Exact sequential test for clinical trials and post-market drug and vaccine safety surveillance with Poisson and binary data ????Stat Med http://www.kidney.de/pget.php?&tw=1&pmid=34120357 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34120357 #FOAvip English Wikipedia <ref>{{Cite pmid|34120357}}</ref> Exact sequential test for clinical trials and post-market drug and vaccine safety surveillance with Poisson and binary data #MMPMID34120357 R Silva I; Maro J; Kulldorff M Stat Med 2021[Sep]; 40 (22): 4890-4913 PMID34120357show ga In sequential analysis, hypothesis testing is performed repeatedly in a prospective manner as data accrue over time to quickly arrive at an accurate conclusion or decision. In this tutorial paper, detailed explanations are given for both designing and operating sequential testing. We describe the calculation of exact thresholds for stopping or signaling, statistical power, expected time to signal, and expected sample sizes for sequential analysis with Poisson and binary type data. The calculations are run using the package Sequential, constructed in R language. Real data examples are inspired on clinical trials practice, such as the current efforts to develop treatments to face the COVID-19 pandemic, and the comparison of treatments of osteoporosis. In addition, we mimic the monitoring of adverse events following influenza vaccination and Pediarix vaccination. |*COVID-19[MESH] |*Pharmaceutical Preparations[MESH] |Humans[MESH] |Pandemics[MESH] |Prospective Studies[MESH]Exact sequential test for clinical trials and post-market drug and vac(epmc).pdf DeepDyve Pubget Overpricing