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Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Infect+Public+Health 2021 ; 14 (7): 898-902 Nephropedia Template TP
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Evaluation of three commercial SARS-CoV-2 serology assays in a tertiary care hospital in the United Arab Emirates #MMPMID34119842
Alatoom A; Atef S; AbdelWareth L; Murthy J; Jones M; Cox G; Harris J; Altrabulsi B
J Infect Public Health 2021[Jul]; 14 (7): 898-902 PMID34119842show ga
BACKGROUND: Serology assays have the potential to support RT-PCR in the diagnosis of SARS-CoV-2 infection. We studied three commercially available immunoassays for their diagnostic accuracy from blood specimens collected from 93 patients. METHODS: Blood samples from patients with confirmed COVID-19 infection were analysed using three different Immunoassays (Roche total antibody assay, Abbott IgG assay and Euroimmun IgG assay). Sensitivity, specificity, precision and time of seroconversion were evaluated. RESULTS: The sensitivity of Roche, Abbott and Euroimmun assays was 38.7%, 35.5% and 25.0% respectively for specimens collected <10 days and 84.4%, 84.4% and 70.0% respectively for specimens collected >/=10 days after the first positive RT-PCR. The specificity of all the three assays in this study was 100%. The timing of seroconversion occurred at day 1, 7 or 14. CONCLUSIONS: The assays evaluated in this study have different sensitivities for detecting antibodies in SARS-CoV-2 infection. Sensitivity for detecting antibodies for all three assays was higher for specimens collected >/=10 days after first positive PCR compared with specimens collected <10 days. Time of seroconversion is variable and assay-dependent.