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10.1016/j.jsbmb.2021.105939 http://scihub22266oqcxt.onion/10.1016/j.jsbmb.2021.105939 34118414!8188774!34118414     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Steroid+Biochem+Mol+Biol 2021 ; 212 (ä): 105939 Nephropedia Template TP {{tp|p=34118414|t=2021. 7-Ketocholesterol: Effects on viral infections and hypothetical contribution in COVID-19 |pdf=|usr=}}{{34118414}} gab.com Text 7-Ketocholesterol: Effects on viral infections and hypothetical contribution in COVID-19 JO: J Steroid Biochem Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=34118414 #FOAvip 7-Ketocholesterol, which is one of the earliest cholesterol oxidization products identified, is essentially formed by the auto-oxidation of cholesterol. In the body, 7-ketocholesterol is both provided by food and produced endogenously. This pro-oxidant and pro-inflammatory molecule, which can activate apoptosis and autophagy at high concentrations, is an abundant component of oxidized Low Density Lipoproteins. 7-Ketocholesterol appears to significantly contribute to the development of age-related diseases (cardiovascular diseases, age-related macular degeneration, and Alzheimer's disease), chronic inflammatory bowel diseases and to certain cancers. Recent studies have also shown that 7-ketocholesterol has anti-viral activities, including on SARS-CoV-2, which are, however, lower than those of oxysterols resulting from the oxidation of cholesterol on the side chain. Furthermore, 7-ketocholesterol is increased in the serum of moderately and severely affected COVID-19 patients. In the case of COVID-19, it can be assumed that the antiviral activity of 7-ketocholesterol could be counterbalanced by its toxic effects, including pro-oxidant, pro-inflammatory and pro-coagulant activities that might promote the induction of cell death in alveolar cells. It is therefore suggested that this oxysterol might be involved in the pathophysiology of COVID-19 by contributing to the acute respiratory distress syndrome and promoting a deleterious, even fatal outcome. Thus, 7-ketocholesterol could possibly constitute a lipid biomarker of COVID-19 outcome and counteracting its toxic effects with adjuvant therapies might have beneficial effects in COVID-19 patients. Twit Text FOAVip 7-Ketocholesterol: Effects on viral infections and hypothetical contribution in COVID-19 ????J Steroid Biochem Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=34118414 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34118414 #FOAvip English Wikipedia <ref>{{Cite pmid|34118414}}</ref> 7-Ketocholesterol: Effects on viral infections and hypothetical contribution in COVID-19 #MMPMID34118414 Ghzaiel I; Sassi K; Zarrouk A; Nury T; Ksila M; Leoni V; Bouhaouala-Zahar B; Hammami S; Hammami M; Mackrill JJ; Samadi M; Ghrairi T; Vejux A; Lizard G J Steroid Biochem Mol Biol 2021[Sep]; 212 (ä): 105939 PMID34118414show ga 7-Ketocholesterol, which is one of the earliest cholesterol oxidization products identified, is essentially formed by the auto-oxidation of cholesterol. In the body, 7-ketocholesterol is both provided by food and produced endogenously. This pro-oxidant and pro-inflammatory molecule, which can activate apoptosis and autophagy at high concentrations, is an abundant component of oxidized Low Density Lipoproteins. 7-Ketocholesterol appears to significantly contribute to the development of age-related diseases (cardiovascular diseases, age-related macular degeneration, and Alzheimer's disease), chronic inflammatory bowel diseases and to certain cancers. Recent studies have also shown that 7-ketocholesterol has anti-viral activities, including on SARS-CoV-2, which are, however, lower than those of oxysterols resulting from the oxidation of cholesterol on the side chain. Furthermore, 7-ketocholesterol is increased in the serum of moderately and severely affected COVID-19 patients. In the case of COVID-19, it can be assumed that the antiviral activity of 7-ketocholesterol could be counterbalanced by its toxic effects, including pro-oxidant, pro-inflammatory and pro-coagulant activities that might promote the induction of cell death in alveolar cells. It is therefore suggested that this oxysterol might be involved in the pathophysiology of COVID-19 by contributing to the acute respiratory distress syndrome and promoting a deleterious, even fatal outcome. Thus, 7-ketocholesterol could possibly constitute a lipid biomarker of COVID-19 outcome and counteracting its toxic effects with adjuvant therapies might have beneficial effects in COVID-19 patients. |Animals[MESH] |Antiviral Agents/*pharmacology[MESH] |Biomarkers/blood[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/blood/*etiology[MESH] |Humans[MESH]7-Ketocholesterol: Effects on viral infections and hypothetical contri(epmc).pdf DeepDyve Pubget Overpricing