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10.1016/j.molcel.2021.05.023 http://scihub22266oqcxt.onion/10.1016/j.molcel.2021.05.023 34118193!8142890!34118193     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34118193&cmd=llinks): Failed to open stream: HTTP request failed! 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Global analysis of protein-RNA interactions in SARS-CoV-2-infected cells reveals key regulators of infection |pdf=|usr=}}{{34118193}} gab.com Text Global analysis of protein-RNA interactions in SARS-CoV-2-infected cells reveals key regulators of infection JO: Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=34118193 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). SARS-CoV-2 relies on cellular RNA-binding proteins (RBPs) to replicate and spread, although which RBPs control its life cycle remains largely unknown. Here, we employ a multi-omic approach to identify systematically and comprehensively the cellular and viral RBPs that are involved in SARS-CoV-2 infection. We reveal that SARS-CoV-2 infection profoundly remodels the cellular RNA-bound proteome, which includes wide-ranging effects on RNA metabolic pathways, non-canonical RBPs, and antiviral factors. Moreover, we apply a new method to identify the proteins that directly interact with viral RNA, uncovering dozens of cellular RBPs and six viral proteins. Among them are several components of the tRNA ligase complex, which we show regulate SARS-CoV-2 infection. Furthermore, we discover that available drugs targeting host RBPs that interact with SARS-CoV-2 RNA inhibit infection. Collectively, our results uncover a new universe of host-virus interactions with potential for new antiviral therapies against COVID-19. Twit Text FOAVip Global analysis of protein-RNA interactions in SARS-CoV-2-infected cells reveals key regulators of infection ????Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=34118193 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34118193 #FOAvip English Wikipedia <ref>{{Cite pmid|34118193}}</ref> Global analysis of protein-RNA interactions in SARS-CoV-2-infected cells reveals key regulators of infection #MMPMID34118193 Kamel W; Noerenberg M; Cerikan B; Chen H; Jarvelin AI; Kammoun M; Lee JY; Shuai N; Garcia-Moreno M; Andrejeva A; Deery MJ; Johnson N; Neufeldt CJ; Cortese M; Knight ML; Lilley KS; Martinez J; Davis I; Bartenschlager R; Mohammed S; Castello A Mol Cell 2021[Jul]; 81 (13): 2851-2867.e7 PMID34118193show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). SARS-CoV-2 relies on cellular RNA-binding proteins (RBPs) to replicate and spread, although which RBPs control its life cycle remains largely unknown. Here, we employ a multi-omic approach to identify systematically and comprehensively the cellular and viral RBPs that are involved in SARS-CoV-2 infection. We reveal that SARS-CoV-2 infection profoundly remodels the cellular RNA-bound proteome, which includes wide-ranging effects on RNA metabolic pathways, non-canonical RBPs, and antiviral factors. Moreover, we apply a new method to identify the proteins that directly interact with viral RNA, uncovering dozens of cellular RBPs and six viral proteins. Among them are several components of the tRNA ligase complex, which we show regulate SARS-CoV-2 infection. Furthermore, we discover that available drugs targeting host RBPs that interact with SARS-CoV-2 RNA inhibit infection. Collectively, our results uncover a new universe of host-virus interactions with potential for new antiviral therapies against COVID-19. |A549 Cells[MESH] |COVID-19/genetics/*metabolism[MESH] |Humans[MESH] |Proteome/genetics/*metabolism[MESH] |RNA, Viral/genetics/*metabolism[MESH] |RNA-Binding Proteins/genetics/*metabolism[MESH] |SARS-CoV-2/*physiology[MESH] |Viral Proteins/genetics/*metabolism[MESH]Global analysis of protein-RNA interactions in SARS-CoV-2-infected cel(epmc).pdf DeepDyve Pubget Overpricing